Publications de Laurent Badel | EPFL Graph Search

Interpretation of neuronal response properties with simplified neuron models

Computational neuroscience is a branch of the neurosciences that attempts to elucidate the principles underlying the operation of neurons with the help of mathematical modeling. In contrast with a number of fields pursuing a tightly related goal, such as m ...

EPFL2009

Extracting non-linear integrate-and-fire models from experimental data using dynamic I – V curves

Wulfram Gerstner, Carl Petersen, Laurent Badel, Thomas Berger, Sandrine Lefort

The dynamic I–V curve method was recently introduced for the efficient experimental generation of reduced neuron models. The method extracts the response properties of a neuron while it is subject to a naturalistic stimulus that mimics in vivo-like fluctua ...

Springer Verlag2008

Dynamic I-V curves are reliable predictors of naturalistic pyramidal-neuron voltage traces

Wulfram Gerstner, Carl Petersen, Laurent Badel, Sandrine Lefort, Romain Brette

Neuronal response properties are typically probed by intracellular measurements of current-voltage (I-V) relationships during application of current or voltage steps. Here we demonstrate the measurement of a novel I-V curve measured while the neuron exhibi ...

American Physiological Society2008

Spike-triggered averages for passive and resonant neurons receiving filtered excitatory and inhibitory synaptic drive

Wulfram Gerstner, Laurent Badel

A path-integral approach is developed for the analysis of spike-triggered-average quantities in neurons with voltage-gated subthreshold currents. Using a linearization procedure to reduce the models to the generalized integrate-and-fire form, analytical ex ...

2008

Quantitative single-neuron modeling: competition 2008

Wulfram Gerstner, Thomas Berger, Richard Naud, Laurent Badel

How well are single-cell properties reproduced by the present-day neuronal models? Recently, several labs have approached this question by assessing the quality of the models with respect to spike timing prediction or characteristic features of the voltage ...

2008

Dependence of the spike-triggered average voltage on membrane response properties

Wulfram Gerstner, Laurent Badel

The spike-triggered average voltage (STV) is an experimentally measurable quantity that is determined by both the membrane response properties and the statistics of the synaptic drive. Here, the form of the STV is modelled for neurons with three distinct t ...

Elsevier2006