Publications de Geoffrey Bodenhausen

Gunther Laukien Prize 2019

Wiley-VCH Verlag GmbH2019

Dynamic Nuclear Polarization of Long-Lived Nuclear Spin States in Methyl Groups

Geoffrey Bodenhausen, Aurélien Bornet, Sami Jannin, Basile Vuichoud, Daniele Mammoli, Arthur César Pinon, Gabriele Stevanato

We have induced hyperpolarized long-lived states in compounds containing C-13-bearing methyl groups by dynamic nuclear polarization (DNP) at cryogenic temperatures, followed by dissolution with a warm solvent. The hyper polarized methyl long-lived states g ...

Amer Chemical Soc2017

Transportable hyperpolarized metabolites

David Lyndon Emsley, Geoffrey Bodenhausen, Aurélien Bornet, Sami Jannin, Aaron James Rossini, Jonas Milani, Basile Vuichoud, Xiao Ji, David Benjamin Roger Antoine Gajan

Nuclear spin hyperpolarization of C-13-labelled metabolites by dissolution dynamic nuclear polarization can enhance the NMR signals of metabolites by several orders of magnitude, which has enabled in vivo metabolic imaging by MRI. However, because of the s ...

Nature Publishing Group2017

Phenylazide Hybrid-Silica - Polarization Platform for Dynamic Nuclear Polarization at Cryogenic Temperatures

Geoffrey Bodenhausen, Aurélien Bornet, Sami Jannin, Jonas Milani, Basile Vuichoud, David Benjamin Roger Antoine Gajan, David Baudouin

Hyperpolarization of NMR-active nuclei is key to gather high quality spectra of rare species and insensitive isotopes. We have recently established that silica-based materials containing regularly distributed nitroxyl radicals connected to the silica matri ...

Wiley-V C H Verlag Gmbh2017

Exciting Wide NMR Spectra of Static Solid Samples with Weak Radiofrequency Fields

Geoffrey Bodenhausen, Diego Carnevale, Srinivas Chinthalapalli

Trains of short pulses in the manner of `delays alternating with nutations for tailored excitation' (DANTE) have been applied to the Pake patterns of protons of water molecules trapped in a static powdered sample of barium chlorate monohydrate. The spin dy ...

Walter De Gruyter Gmbh2017

Hyperpolarization of nitrogen-15 nuclei by cross polarization and dissolution dynamic nuclear polarization

Geoffrey Bodenhausen, Aurélien Bornet, Sami Jannin, Jonas Milani, Basile Vuichoud

Dynamic Nuclear Polarization (DNP) is often achieved by the direct transfer of polarization from electrons to nuclei such as C-13, induced by microwave saturation of the wings of narrow EPR lines of radicals like trityl. In the indirect approach on the oth ...

Amer Inst Physics2017

Transportable long-lived hyperpolarized samples

David Lyndon Emsley, Geoffrey Bodenhausen, Sami Jannin

A method for the preparation of a hyperpolarized solution of molecules comprises the steps: 1) suspending or coating of a micro-particulate matrix, which is comprising or consisting of the molecules, with a glass-forming solution or suspension comprising a ...

2016

Dissolution dynamic nuclear polarization of deuterated molecules enhanced by cross-polarization

Geoffrey Bodenhausen, Sami Jannin, Jonas Milani, Estel Canet Martinez, Daniel Abergel, Sina Marhabaie, Matthias Weller

We present novel means to hyperpolarize deuterium nuclei in (CD2)-C-13 groups at cryogenic temperatures. The method is based on cross-polarization from H-1 to C-13 and does not require any radio-frequency fields applied to the deuterium nuclei. After rapid ...

Amer Inst Physics2016

Ligand-Protein Affinity Studies Using Long-Lived States of Fluorine-19 Nuclei

Geoffrey Bodenhausen, Daniele Mammoli, Roberto Buratto, Estel Canet Martinez

The lifetimes T-LLS of long-lived states or T-LLC of long-lived coherences can be used for the accurate determination of dissociation constants of weak protein ligand complexes. The remarkable contrast between signals derived from LLS or LLC in free and bo ...

American Chemical Society2016

Highly Repeatable Dissolution Dynamic Nuclear Polarization for Heteronuclear NMR Metabolomics

Geoffrey Bodenhausen, Aurélien Bornet, Sami Jannin, Jonas Milani, Basile Vuichoud, Xiao Ji

At natural C-13 abundance, metabolomics based on heteronuclear NMR is limited by sensitivity. We have recently demonstrated how hyperpolarization by dissolution dynamic nuclear polarization (D-DNP) assisted by cross-polarization (CP) provides a reliable wa ...

Amer Chemical Soc2016