Publications de Luca Gambazzi | EPFL Graph Search

Method for in-vitro monitoring of neuronal disorders and use thereof

Henry Markram, Michele Giugliano, Luca Gambazzi

The present invention relates to methods and neuronal cellular preparations allowing monitoring intracellular and transcellular molecular events on both short and long timescales in an ex vivo neuronal network of intact post-mitotic neurons. In particular, ...

2012

Multiwalled Carbon-Nanotube-Functionalized Microelectrode Arrays Fabricated by Microcontact Printing: Platform for Studying Chemical and Electrical Neuronal Signaling

Michele Giugliano, Luca Gambazzi

A facile method is proposed for the deposition of multiwalled carbon nanotube (MWCNT) layers onto microelectrode arrays by means of a microcontact printing technique, leading to the fabrication of MEAs characterized by well defined electrical and morpholog ...

2011

Impact of Carbon-Nanotube Substrate Coating in Neuronal Networks

Luca Gambazzi

The interest in new materials and their application in the neuroscience are growing incredibly fast. Current research interests are increasingly focusing on new artificial materials and their direct effects on the central nervous systems so that it would b ...

EPFL2010

Diminished activity-dependent brain-derived neurotrophic factor expression underlies cortical neuron microcircuit hypoconnectivity resulting from exposure to mutant huntingtin fragments

Henry Markram, Michele Giugliano, Elena Katsyuba, Ozgün Gökce, Heike Runne, Luca Gambazzi

Although previous studies of Huntington's disease (HD) have addressed many potential mechanisms of striatal neuron dysfunction and death, it is also known, based on clinical findings, that cortical function is dramatically disrupted in HD. With respect to ...

American Society for Pharmacology and Experimental Therapeutics2010

Carbon nanotubes might improve neuronal performance by favouring electrical shortcuts

Henry Markram, Michele Giugliano, Luca Gambazzi

Carbon nanotubes have been applied in several areas of nerve tissue engineering to probe and augment cell behaviour, to label and track subcellular components, and to study the growth and organization of neural networks. Recent reports show that nanotubes ...

Nature Publishing Group2009

Interfacing neurons with carbon nanotubes: electrical signal transfer and synaptic stimulation in cultured brain circuits

Henry Markram, Michele Giugliano, Luca Gambazzi

The unique properties of single-wall carbon nanotubes (SWNTs) and the application of nanotechnology to the nervous system may have a tremendous impact in the future developments of microsystems for neural prosthetics as well as immediate benefits for basic ...

2007