Publications de Dominique Seppey

Intercellular calcium waves are associated with the propagation of vasomotion along arterial strips

Jean-Jacques Meister, Jean-Louis Bény, Roger Sauser, Dominique Seppey, Michèle Koenigsberger

Vasomotion consists of cyclic arterial diameter variations induced by synchronous contractions and relaxations of smooth muscle cells. However, the arteries do not contract simultaneously on macroscopic distances, and a propagation of the contraction can b ...

2010

Mechanisms of Propagation of Intercellular Calcium Waves in Arterial Smooth Muscle Cells

Jean-Jacques Meister, Jean-Louis Bény, Dominique Seppey, Michèle Koenigsberger

In rat mesenteric arteries, smooth muscle cells exhibit intercellular calcium waves in response to local phenylephrine stimulation. These waves have a velocity of similar to 20 cells/s and a range of similar to 80 cells. We analyze these waves in a theoret ...

Elsevier2010

Intercellular calcium dynamics in smooth muscle cells : propagation of arterial vasomotion and influence of the endothelium

Dominique Seppey

Muscular arteries are able to actively modify their diameter by modulating the tone of the smooth muscle cells located within the arterial wall. A small variation of lumen diameter has a large influence on blood flow as well as on arterial pressure. The ca ...

EPFL2009

Calcium dynamics and vasomotion in arteries subject to isometric, isobaric, and isotonic conditions

Jean-Jacques Meister, Jean-Louis Bény, Roger Sauser, Dominique Seppey, Michèle Koenigsberger

In vitro, different techniques are used to study the smooth muscle cells' calcium dynamics and contraction/relaxation mechanisms on arteries. Most experimental studies use either an isometric or an isobaric setup. However, in vivo, a blood vessel is neithe ...

2008

Does the Endothelium Abolish or Promote Arterial Vasomotion in Rat Mesenteric Arteries? Explanations for the Seemingly Contradictory Effects

Jean-Jacques Meister, Jean-Louis Bény, Roger Sauser, Dominique Seppey, Michèle Koenigsberger

Karger2008