Publications de Mélanie Favre

Optimization of thin-film highly-compliant elastomer sensors for contractility measurement of muscle cells

Herbert Shea, Cristina Martin Olmos, Matthias Imboden, Samuel Rosset, Alexandre Poulin, Francesca Sorba, Mélanie Favre, Oluwaseun Adelowo Araromi

Test assays capable of providing quantitative characterization of the contraction of cardiac and smooth muscle cells are of great need for drug development and screening. Several methodologies have been proposed for achieving measurement of cell contractil ...

Elsevier Science Bv2016

Parallel AFM imaging and force spectroscopy using two-dimensional probe arrays for applications in cell biology

Peter Vettiger, Harry Heinzelmann, Mélanie Favre, Martha Liley, André Meister

Atomic force microscopy (AFM) investigations of living cells provide new information in both biology and medicine. However, slow cell dynamics and the need for statistically significant sample sizes mean that data collection can be an extremely lengthy pro ...

Wiley-Blackwell2011

Force spectroscopy of barnase-barstar single molecule interaction

Giovanni Dietler, Serguei Sekatski, Mélanie Favre, Dmitry Klinov, Andrey Mikhaylov

Results of the single molecule force spectroscopy study of specific interactions between ribonuclease barnase and its inhibitor barstar are presented. Experimental data obtained for the force loading rate ranging 2-70 nN/s are well approximated by a single ...

Wiley-Blackwell2010

Complex studies of interactions between flaviviruses and laminin binding protein

Giovanni Dietler, Serguei Sekatski, Mélanie Favre

2009

Physical properties and interactions of biomolecules : an atomic force microscopy study

Mélanie Favre

The aim of this thesis was to explore the statistical physics and the mechanical properties of individual biomolecules, to study their interactions, and to develop new techniques based on atomic force microscopy (AFM). First, we exploit the high resolution ...

EPFL2008

Immunochernical and single molecule force spectroscopy studies of specific interaction between the laminin binding protein and the West Nile virus surface glycoprotein E domain II

Giovanni Dietler, Serguei Sekatski, Mélanie Favre

ELISA and Western blot immunochemical data attest an effective and highly specific interaction of the surface glycoprotein E domain II (DII) of the tick born encephalitis and Dengue viruses with the laminin binding protein (LBP). Based on a highly conserva ...

2008

Single-molecule avidin-biotin association reaction studied by force-clamp spectroscopy

Giovanni Dietler, Serguei Sekatski, Mélanie Favre

Using single-molecule force-clamp spectroscopy, where the distance between the AFM tip and the sample surface is fixed and a few parallel avidin-biotin complexes are kept stretched by a certain force, we were able to observe the formation of single avidin- ...

2008

Interactive measurement and characterization of DNA molecules by analysis of AFM images

Giovanni Dietler, Mélanie Favre

2005

Scaling exponents and probability distributions of DNA end-to-end distance

Giovanni Dietler, Paolo De Los Rios, Mélanie Favre

2005