Alke Fink

Cette personne n’est plus à l’EPFL

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Publications associées (48)

Positional Control of Superparamagnetic Iron Oxide Nanoparticles in Silica Beads U

Heinrich Hofmann, Alke Fink, Benedikt Steitz, Sandrine Gay, Franziska Krauss

2007

Fixed bed reactor for solid phase surface derivatization of superparamagnetic nanoparticles

Heinrich Hofmann, Alke Fink, Benedikt Steitz, Andrija Finka, Jatuporn Salaklang

The functionalization of nanoparticles is conditio sine qua non in studies of specific interaction with a biological target. Often, their biological functionality is achieved by covalent binding of bioactive molecules on a preexisting single surface coatin ...

2007

INJECTABLE SUPERPARAMAGNETIC NANOPARTICLES FOR TREATMENT BY HYPERTHERMIA AND USE FOR FORMING AN HYPERTHERMIC IMPLANT

Heinrich Hofmann, Alke Fink, Mathieu Chastellain, Olivier Jordan

The injectable formulation for treatment by hyperthermia comprises a liquid carrier and heat-generating superparamagnetic iron oxide nanoparticles having a mean diameter not greater than 20 nm. Said injectable formulation is able to form in-situ a hyperthe ...

2006

Nanoparticules à noyau métallique recouvert de silice

Heinrich Hofmann, Alke Fink

The invention relates to nanoparticles based on a metal, on a metal alloy or on a metal derivative coated with a silica layer, in which the silica is crystalline silica, in particular crystalline silica in the cristobalite form. They may be prepared from n ...

2006

Systemic Distribution and Elimination of Plain and with Cy3.5 Functionalized Poly(vinyl alcohol) Coated Superparamagnetic Maghemite Nanoparticles After Intraarticular Injection in Sheep In Vivo

Heinrich Hofmann, Alke Fink, Benedikt Steitz

PVA coated and fluorescent dye (Cy3.5) functionalized vinyl alcohol/vinyl amine copolymer coated superparamagnetic iron oxide nanoparticles (SPION) were evaluated for systemic distribution and elimination after intraarticular injection in sheep. Observatio ...

2006

Gene Expression in Synovial Membrane Cells After Intraarticular Delivery of Plasmid-Linked Superparamagnetic Iron Oxide Particles—A Preliminary Study in Sheep

Heinrich Hofmann, Alke Fink, Benedikt Steitz

This study evaluated in vivo gene deliver y and subsequent gene expression within cells of the synovium in the presence of static and pulsating magnetic field application following intraar ticular injection of super paramagnetic iron oxide nanopar ticles l ...

2006

A mixture of ferritin and magnetite nanoparticles mimics the magnetic properties of human brain tissue

Alke Fink

Magnetic properties of a two-component system, consisting of horse spleen ferritin ...

2006

Interaction of Functionalized Superparamagnetic Iron Oxide Nanoparticles with Brain Structures

Heinrich Hofmann, Alke Fink

Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) com-bined with magnetic resonance imaging (MRI) are under clinical evaluation to enhance detection of neurodegenerative diseases. A major improvement would be to link therapeutic drugs to the SPIONs to a ...

2006

Pièce en céramique pigmentée

Heinrich Hofmann, Alke Fink

NOVELTY - The component partially or wholly comprises pigmented ceramic. The pigment comprises nanoparticles of metal of group IB in periodic table, alkaline metals or their alloy, coated with a layer of silica such as crystalline silica. The crystalline s ...

2006

Uptake and Biocompatibility of Functionalized Poly(vinylalcohol) Coated Superparamagnetic Maghemite Nanoparticles by Synoviocytes In Vitro

Heinrich Hofmann, Alke Fink, Benedikt Steitz

Superparamagnetic iron oxide nanoparticles (SPION) were coated with either Polyvinyl alcohol (PVA) or Vinyl alcohol/vinyl amine copolymer and further functionalized with the fluorochromes Cy3.5 or Texas Red. A colloidally stable suspension of nanoparticles ...

2006

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