Publications de Lynda Metref | EPFL Graph Search

Portable Technologies for Self-Monitoring of Coagulation Time: A Review

Anti-coagulation treatments are required for medical conditions that become more and more frequent with the ageing of the population in developed countries (atrial fibrillation, deep-venous thrombosis, heart prosthetic valves, etc.). These treatments gener ...

2012

Fluid Manipulation Using Thermoexpandable Polymer Based on Ploydimethylsiloxane and Expancel

Lynda Metref

Nowadays, manipulation of liquids in miniaturised environments finds applications in many fields in biology and medicine such as diagnostics, toxicity analysis, drug delivery and so on. In those domains, the use of disposable devices has the great advantag ...

EPFL2010

Microfluidic system based on thermoexpandable polymer for on chip blood coagulation testing

Philippe Renaud, Lynda Metref, Raphaël Goetschmann, François Bianchi

This paper describes a simple system for the actuation of a biological fluid through micro-channels with a thermoactivated polymer actuator. This system is of interest for the development of single-use diagnostic test-strips since the actuation of the samp ...

2009

On-chip thermopneumatic actuation system for coagulation time measurement

Philippe Renaud, Lynda Metref, Pierre Lemaire, François Bianchi

This work reports the demonstration of a thermopneumatic microfluidic actuator used to determine blood coagulation time. In this new system, the detection principle is the obstruction of a microfluidic channel by clotted blood. The sample actuation is done ...

Elsevier2009

A simple pneumatic setup for driving microfluidics

Philippe Renaud, Thomas Michael Braschler, Harald Van Lintel, Nicolas Demierre, Lynda Metref, Joël Theytaz

2007

Contactless electrochemical actuator for precise sampling on microchip

Martinus Gijs, Lynda Metref, Daniel Berdat

The scope of this work has been the design of a mechanical actuator in polydimethylsiloxane (PDMS) / glass for precise liquid sampling, based on the electrochemical generation of O2. The device is composed of two chambers separated by a PDMS membrane. In t ...

2005

Gentle cell trapping and release on a microfluidic chip by in situ alginate hydrogel formation

Philippe Renaud, Thomas Michael Braschler, Lynda Metref

Microfluidic devices are increasingly used to perform biological experiments on a single-cell basis. However, long-term stability of cell positions is still an issue. A novel biocompatible method for cell entrapment and release on a microchip is presented. ...

2005