Personne

Nicolas Dorsaz

Publications associées (27)

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Liquid–liquid phase separation occurs in young mammalian eye lenses and in concentrated solutions of isolated eye lens proteins, and has been linked to some forms of cataract. Here we study theoretically the protein compositions and cloud temperatures of t ...

2011

Confined shocks inside isolated liquid volumes: A new path of erosion?

Mohamed Farhat, Nicolas Dorsaz, Danail Obreschkow, Philipp Kobel, Aurèle De Bosset, Marc Tinguely

The unique confinement of shock waves inside isolated liquid volumes amplifies the density of shock–liquid interactions. We investigate this universal principle through an interdisciplinary study of shock-induced cavitation inside liquid volumes, isolated ...

American Institute of Physics2011

Crowding, Intermolecular Interactions, and Shear Flow Effects in the Diffusion Model of Chemical Reactions

Nicolas Dorsaz, Giuseppe Foffi, Francesco Piazza

In the diffusion model of chemical reactions, the encounter (reaction) rate between reactant particles is governed by the Smoluchowski equation, which is a diffusion equation in a field of forces. We consider crowded environments where the particles diffus ...

2011

We study the phase behaviour of symmetric binary mixtures of hard core Yukawa (HCY) particles via thermodynamic perturbation theory (TPT). We show that all the topologies of phase diagram reported for the symmetric binary mixtures are correctly reproduced ...

2010

Inertial effects in diffusion-limited reactions

Nicolas Dorsaz, Giuseppe Foffi, Francesco Piazza

Diffusion-limited reactions are commonly found in biochemical processes such as enzyme catalysis, colloid and protein aggregation and binding between different macromolecules in cells. Usually, such reactions are modeled within the Smoluchowski framework b ...

Institute of Physics2010

Diffusion-Limited Reactions in Crowded Environments

Paolo De Los Rios, Nicolas Dorsaz, Giuseppe Foffi, Francesco Piazza

Diffusion-limited reactions are usually described within the Smoluchowski theory, which neglects interparticle interactions. We propose a simple way to incorporate excluded-volume effects building on simulations of hard sphere in the presence of a sink. Fo ...

American Physical Society2010

A colloidal approach to eye lens protein mixtures

Nicolas Dorsaz

A broad and constantly growing class of diseases, such as Alzheimer's disease, sickle-cell or cataract, involves protein association phenomena as an essential aspect. The common denominator of all the members of this class of molecular condensation disease ...

EPFL2009

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This paper describes the techniques and physical parameters used to produce stable centimetric water drops in microgravity, and to study single cavitation bubbles inside such drops (Parabolic Flight Campaigns, European Space Agency ESA). While the main sci ...

2009

Colloidal characterization and thermodynamic stability of binary eye lens protein mixtures

Nicolas Dorsaz, Giuseppe Foffi

We present a study of binary mixtures of eye lens crystallin proteins. A coarse-grained model of aqueous aand γ-crystallin mixtures based on molecular dynamics simulations and SANS experiments is proposed. Thermodynamic perturbation theory is implemented t ...

2009

Spinodal surface of a free energy model for eye lens protein mixtures: Relevance for cataracts

Nicolas Dorsaz, Giuseppe Foffi

We studied the phase behavior of a model binary mixture of eye lens crystallin proteins using first-order thermodynamic perturbation theory. The instability boundary, or spinodal surface, was found to be very sensitive to the strength of the attraction bet ...

Amer Inst Physics, 2 Huntington Quadrangle, Ste 1No1 D, Melville, Ny 11747-4501 Usa2009