Publications de Sébastien Rochat

Fluorescence sensing of caffeine in water with polysulfonated pyrenes

Kay Severin, Anne-Clémence Corminboeuf, Sébastien Rochat

The commercially available fluorescence dye 8-hydroxypyrene-1,3,6-trisulfonate (HPTS) can be used as a selective molecular probe for the detection of caffeine in aqueous solution. ...

Royal Society of Chemistry2011

A simple fluorescence assay for the detection of fluoride in water at neutral pH

Kay Severin, Sébastien Rochat

A simple assay for the detection of fluoride in water by fluorescence spectroscopy was developed. The assay is based on commercially available reagents and allows sensing of fluoride in the low millimolar concentration range with high selectivity over othe ...

Royal Society of Chemistry2011

Fluorescence Sensors for Lithium Ions and Small Peptides

Kay Severin, Sébastien Rochat

Simple but powerful chemosensors were developed by taking advantage of self-assembly processes. First, we will describe a turn-on fluorescent sensor for the pharmacologically important lithium ion. The sensor can be used in purely aqueous solution, and it ...

Schweizerische Chemische Gesellschaft2010

Metal-Based Chemosensors for Important Bioanalytes

Sébastien Rochat

This work describes different strategies for the detection of biologically relevant analytes. The main goal was to achieve sensing in water, which is a prerequisite for application to real biological samples. In several cases, we could demonstrate that our ...

EPFL2010

Pattern-Based Sensing with Metal−Dye Complexes: Sensor Arrays versus Dynamic Combinatorial Libraries

Kay Severin, Sébastien Rochat

The dyes Methyl Calcein Blue, Arsenazo I, and Xylenol Orange, and the metal salts CuCl2 and NiCl2 were used to generate colorimetric sensors for peptides. Two different approaches were followed: (1) Sensors based on dynamic combinatorial libraries of metal ...

American Chemical Society2010

Cross-Reactive Sensor Arrays for the Detection of Peptides in Aqueous Solution by Fluorescence Spectroscopy

Kay Severin, Sébastien Rochat, Friederike Gundula Marie Zaubitzer, Jie Gao

A simple but powerful method for the sensing of peptides in aqueous solution has been developed. The transition-metal complexes [PdCl2(en)], [{RhCl2Cp*}2], and [{RuCl2(p-cymene)} 2] were combined with six different fluorescent dyes to build a cross-reactiv ...

2010

Ruthenium-based metallacrown complexes for the selective detection of lithium ions in water and in serum by fluorescence spectroscopy

Kay Severin, Zacharias Immanuel Grote, Sébastien Rochat

Fluorescent dihydroxypyridine ligands were prepared by attaching pyrene-, dansyl-, and methoxycoumarin-fluorophores via dimethyleneamine linkers. The reaction of these ligands with [(p-cymene)RuCl2]2 or [(C6H5CH2NMe2H)RuCl2]2Cl2 resulted in the formation o ...

2009

Influence of Hydrogen-Bonding Substituents on the Cytotoxicity of RAPTA Compounds

Paul Joseph Dyson, Ursula Röthlisberger, Ivano Tavernelli, Christian Gossens, Claudine Scolaro, Sébastien Rochat, Antoine Dorcier, Gianni Sava

A new series of organometallic ruthenium(II)-arene compounds of the type RuCl2(η6-arene)(phosphine) (phosphine = 1,3,5-triaza-7-phosphaadamantane, PTA, and 3,7-diacetly-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane, DAPTA) with different ...

2006