Publications de Simone Bonazzi

Anguinomycins and Derivatives: Total Syntheses, Modeling, and Biological Evaluation of the Inhibition of Nucleocytoplasmic Transport

Karl Gademann, Simone Bonazzi, Jean-Yves Wach, Ivo Zemp

The preparation of the polyketide natural products anguinomycin C and D is reported based on key steps such as Negishi stereoinversion cross coupling, Jacobsen Cr(III)-catalyzed Hetero Diels−Alder reaction, Evans B-mediated syn-aldol chemistry, and B-alkyl ...

2010

Synthetic Studies on the Sporolides: Exploration of the Enediyne Route

Karl Gademann, Simone Bonazzi, Jean-Yves Wach, Cindy Fellay, Massimo Binaghi

Synthetic studies towards the construction of the cyclopenta[a]indene fragment of the heptacyclic marine metabolite sporolide are reported based on a hypothetical biosynthesis. The key step of this biogenetic proposal includes a Bergman cyclization of an e ...

Georg Thieme Verlag2010

Antimalarial and antitubercular nostocarboline and eudistomin derivatives: synthesis, in vitro and in vivo biological evaluation

Stewart Cole, Rosario Scopelliti, Luc Patiny, Karl Gademann, Simone Bonazzi

The synthesis of nine nostocarboline derivatives with substitutions of the 2-methyl group by alkyl, aryl and functionalized residues, 10 symmetrical bis cationic dimers linking 6-Cl-norharmane through the 2-position and fifteen derivatives of the marine al ...

2010

Antimicrobial Surfaces through Natural Product Hybrids

Karl Gademann, Simone Bonazzi, Jean-Yves Wach

The power of two! A natural product hybrid (see structure) composed of a siderophore and an antibiotic separated by a poly(ethylene glycol) linker enables the preparation of antimicrobial and cell-resistant surfaces by a simple dip-and-rinse procedure. The ...

Wiley-VCH Verlag GmbH2008

Protein-Resistant Surfaces through Mild Dopamine Surface Functionalization

Karl Gademann, Simone Bonazzi, Jean-Yves Wach

The synthesis and evaluation of new dopamine-based catechol anchors coupled to poly(ethylene glycol) (PEG) for surface modification of TiO2 are reported. Dopamine is modified by dimethylamine-methylene or trimethylammonium- methylene groups, and the prepar ...

2008

Total Synthesis, Configuration, and Biological Evaluation of Anguinomycin C

Karl Gademann, Simone Bonazzi, Ivo Zemp

Immunofluorescence assays indicate that anguinomycin C is a potent inhibitor of protein export from the nucleus. Key features in the total synthesis of this antitumor natural product include a Cr-catalyzed enantioselective hetero-Diels– Alder reaction, a N ...

Wiley-VCH Verlag GmbH2007

Simone Bonazzi

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Anguinomycins and Derivatives: Total Syntheses, Modeling, and Biological Evaluation of the Inhibition of Nucleocytoplasmic Transport

Synthetic Studies on the Sporolides: Exploration of the Enediyne Route

Antimalarial and antitubercular nostocarboline and eudistomin derivatives: synthesis, in vitro and in vivo biological evaluation

Antimicrobial Surfaces through Natural Product Hybrids

Protein-Resistant Surfaces through Mild Dopamine Surface Functionalization

Total Synthesis, Configuration, and Biological Evaluation of Anguinomycin C

Total Synthesis of Complex Cyanobacterial Alkaloids Without Using Protecting Groups

Combining Devices and Drugs by Synthetic Natural Product Hybrids

Bridged Dihydroxypyridine Ligands for the Synthesis of Expanded Helicates

Synthetic Studies on the Sporolides: Exploration of the Enediyne Route

Protein-Resistant Surfaces through Mild Dopamine Surface Functionalization

Antimalarial and antitubercular nostocarboline and eudistomin derivatives: synthesis, in vitro and in vivo biological evaluation

Antimicrobial Surfaces through Natural Product Hybrids

Combining Devices and Drugs by Synthetic Natural Product Hybrids

Bridged Dihydroxypyridine Ligands for the Synthesis of Expanded Helicates

Anguinomycins and Derivatives: Total Syntheses, Modeling, and Biological Evaluation of the Inhibition of Nucleocytoplasmic Transport

Total Synthesis, Configuration, and Biological Evaluation of Anguinomycin C

Total Synthesis of Complex Cyanobacterial Alkaloids Without Using Protecting Groups