Publications de Sonia Dos Santos

Switch-peptides: from conformational studies to Alzheimer's disease

Hilal Lashuel, Karine Murat, Richard Alan Mimna, Jacques Dubochet, Lydiane Jeanine Saucède, Sonia Dos Santos, Marie-Stéphanie Camus, Jérémy Bérard

A review. Studies on designed peptides that exhibit high tendencies for medium-induced conformational transitions have recently attracted much attention because structural changes are considered as mol. key processes in degenerative diseases. The exptl. ac ...

2006

Switch-peptides as folding precursors in amyloid fibrillogenesis

Sonia Dos Santos, Richard Alan Mimna, Karine Murat, Lydiane Jeanine Saucède, Marie-Stéphanie Camus, Jérémy Bérard

Intramol. O,N-acyl migration reactions were used as structural switch (S-elements) from a depsipeptide bond contg., unfolded state (Soff) to an all-amide, native states (Son). Chem. or enzymically triggered acyl migrations allowed for the controlled induct ...

2006

Switch on amyloid beta peptide self-assembly by enzyme-triggered acyl migration

Sonia Dos Santos, Richard Alan Mimna, Karine Murat, Lydiane Jeanine Saucède, Marie-Stéphanie Camus

2005

Switch-peptides: controlling biological function and self-assembly of amyloid ß-derived peptides using enzyme-triggered acyl migrations

Sonia Dos Santos

Conformational transitions of peptides and proteins have recently moved to the center of interest in various domains of research at the interface of chemistry, biology, and medicine due to their implication in an increasing number of diseases in which the ...

EPFL2005

Switch-peptides: Controlling self-assembly of amyloid beta-derived peptides in vitro by consecutive triggering of acyl migrations

Sonia Dos Santos, Richard Alan Mimna, Karine Murat, Lydiane Jeanine Saucède

2005