Publications de Jens Nielsen | EPFL Graph Search

MEMOTE for standardized genome-scale metabolic model testing

Vassily Hatzimanikatis, Meriç Ataman, Georgios Fengos, Cheng Zhang, Jens Nielsen, Ali Kaafarani

NATURE PUBLISHING GROUP2020

Molecular Mechanism of Flocculation Self-Recognition in Yeast and Its Role in Mating and Survival

Sandor Kasas, Livan Bladimir Alonso Sarduy, Jens Nielsen

We studied the flocculation mechanism at the molecular level by determining the atomic structures of N-Flo1p and N-Lg-Flo1p in complex with their ligands. We show that they have similar ligand binding mechanisms but distinct carbohydrate specificities and ...

American Society for Microbiology2015

Metabolic Needs and Capabilities of Toxoplasma gondii through Combined Computational and Experimental Analysis

Vassily Hatzimanikatis, Stepan Tymoshenko, Rebecca Oppenheim, Jens Nielsen, Dominique Soldati-Favre

Toxoplasma gondii is a human pathogen prevalent worldwide that poses a challenging and unmet need for novel treatment of toxoplasmosis. Using a semi-automated reconstruction algorithm, we reconstructed a genome-scale metabolic model, ToxoNet1. The reconstr ...

Public Library Science2015

Do genome-scale models need exact solvers or clearer standards?

Vassily Hatzimanikatis, Jens Nielsen

Wiley-Blackwell2015

Kinetic models in industrial biotechnology - Improving cell factory performance

Vassily Hatzimanikatis, Jens Nielsen

An increasing number of industrial bioprocesses capitalize on living cells by using them as cell factories that convert sugars into chemicals. These processes range from the production of bulk chemicals in yeasts and bacteria to the synthesis of therapeuti ...

Academic Press Inc Elsevier Science2014