Publications de Paolo Angelino

Orb5: A global electromagnetic gyrokinetic code using the PIC approach in toroidal geometry

Laurent Villard, Stephan Brunner, Emmanuel Lanti, Sébastien Jolliet, Alberto Bottino, Thibaut Vernay, Ben McMillan, Paolo Angelino, Julien Stanislas Pierre Dominski, Noé Thomas Elie Ohana

This paper presents the current state of the global gyrokinetic code Orb5 as an update of the previous reference (Jolliet et al., 2007). The Orb5 code solves the electromagnetic Vlasov–Maxwell system of equations using a PIC scheme and also includes collis ...

2019

Analysis of NGS-based blood immune cell RNA signatures for colorectal cancer detection

Stephan Morgenthaler, Paolo Angelino, Helen Lindsay, Sahar Hosseinian Ehrensberger

OXFORD UNIV PRESS2019

Mutant CTNNB1 and histological heterogeneity define metabolic subtypes of hepatoblastoma

Olivier Michielin, Etienne Meylan, Paolo Angelino, Mauro Delorenzi, Jessica Christine Vazquez, Pierre-Benoit Bernard Ancey, Stefania Crippa

Hepatoblastoma is the most common malignant pediatric liver cancer. Histological evaluation of tumor biopsies is used to distinguish among the different subtypes of hepatoblastoma, with fetal and embryonal representing the two main epithelial components. W ...

2017

RIP4 inhibits STAT3 signaling to sustain lung adenocarcinoma differentiation

Nadine Fournier, Etienne Meylan, Paolo Angelino, Jawahar Kopparam, Mauro Delorenzi, Alessandra Piersigilli, Johanna Pauline Chiffelle

Loss of epithelial differentiation and extracellular matrix (ECM) remodeling are known to facilitate cancer progression and are associated with poor prognosis in patients with lung cancer. We have identified Receptor-interacting serine/threonine protein ki ...

Nature Publishing Group2017

A method for analysis and design of metabolism using metabolomics data and kinetic models: Application on lipidomics using a novel kinetic model of sphingolipid metabolism

Vassily Hatzimanikatis, Paolo Angelino, Howard Riezman, Georgios Savoglidis

We present a model-based method, designated Inverse Metabolic Control Analysis (IMCA), which can be used in conjunction with classical Metabolic Control Analysis for the analysis and design of cellular metabolism. We demonstrate the capabilities of the met ...

Academic Press Inc Elsevier Science2016

The consensus molecular subtypes of colorectal cancer

Douglas Hanahan, Anguraj Sadanandam, Krisztian Homicsko, Sarah Gerster, Paolo Angelino, Mauro Delorenzi, Xin Wang

Colorectal cancer (CRC) is a frequently lethal disease with heterogeneous outcomes and drug responses. To resolve inconsistencies among the reported gene expression-based CRC classifications and facilitate clinical translation, we formed an international c ...

Nature Publishing Group2015

Global Gyrokinetic ITG Turbulence Simulations of ITER

Laurent Villard, Stephan Brunner, Trach-Minh Tran, Alberto Bottino, Sébastien Jolliet, Ben McMillan, Paolo Angelino, Thibaut Vernay

Global gyrokinetic simulations of ion temperature gradient (ITG) driven turbulence in an ideal MHD ITER equilibrium plasma are performed with the ORB5 code. The noise control and field-aligned Fourier filtering procedures implemented in ORB5 are essential ...

Institute of Physics2013

Recent TCV results – innovative plasma shaping to improve plasma properties and insight

Basil Duval, Olivier Sauter, Stefano Coda, Timothy Goodman, Jean-Marc Moret, Laurent Villard, Benoît Labit, Laurie Porte, Holger Reimerdes, Alexander Karpushov

2012

Parallel filtering in global gyrokinetic simulations

Laurent Villard, Stephan Brunner, Trach-Minh Tran, Alberto Bottino, Sébastien Jolliet, Paolo Angelino, Ben McMillan, Thibaut Vernay

In this work, a Fourier solver [B.F. McMillan, S. Jolliet, A. Bottino, P. Angelino, T.M. Tran, L Villard, Comp. Phys. Commun. 181 (2010) 7151 is implemented in the global Eulerian gyrokinetic code GT5D [Y. Idomura, H. Urano, N. Aiba, S. Tokuda, Nucl. Fusio ...

Elsevier2012

Predictions on heat transport and plasma rotation from global gyrokinetic simulations

Laurent Villard, Trach-Minh Tran, Alberto Bottino, Sébastien Jolliet, Paolo Angelino, Ben McMillan

Flux-driven global gyrokinetic codes are now mature enough to make predictions in terms of turbulence and transport in tokamak plasmas. Some of the recent breakthroughs of three such codes, namely GYSELA, ORB5 and XGC1, are reported and compared wherever a ...

IOP Publishing Ltd2011