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Improving the productivity of fed-batch filamentous fungal fermentations can be formulated as a dynamic optimization problem. However, numerical optimization based on a nominal process model is typically insufficient when uncertainty in the form of model m ...
State estimation is a necessary component of advanced monitoring and control techniques, since these techniques often require information that is too expensive or impossible to obtain from direct measurements. The objective of estimation is the reconstruct ...
The sensitivity of the unmeasured state variables to the measurements strongly affects the rate of convergence of a state estimation algorithm. To overcome potential observability problems, the approach has been to identify the model parameters so as to re ...
Industrial filamentous fungal fermentations are typically operated in fed- batch mode. Oxygen control represents an important operational challenge due to the varying biomass concentration. In this study, oxygen control is implemented by manipulating the s ...
In fluidized-bed gas-phase polymerization reactors, several grades of polyethylene are produced in the same equipment by changing the operating conditions. Transitions between the different grades are rather slow and result in the production of a considera ...
State estimation is a widely used concept in the control community, and the literature mostly concentrates on the estimation of all states. However, in soft sensor problems, the emphasis is on estimating a few soft outputs as accurately as possible. The co ...
Integral observers are useful tools for estimating the plant states in the presence of non-vanishing disturbances resulting from plant-model mismatch and exogenous disturbances. It is well known that these observers can eliminate bias in all states, given ...