Publications de Laurent Décosterd

Treatment of pleural malignancies by photo-induction combined to systemic chemotherapy: Proof of concept on rodent lung tumors and feasibility study on porcine chest cavities

Georges Wagnières, Michaël Bensimon, Elodie Debefve, Laurent Décosterd, Jean Yannis Perentes

Background: Low-dose, Visudyne (R)-mediated photodynamic therapy (photo-induction) was shown to selectively enhance tumor vessel transport causing increased uptake of systemically administered chemotherapy in various tumor types grown on rodent lungs. The ...

Wiley-Blackwell2015

Label-Free Detection of Tobramycin in Serum by Transmission-Localized Surface Plasmon Resonance

Carlotta Guiducci, Thierry Buclin, Anna Ferretti, Giulia Cappi, Fabio Mario Spiga, Laurent Décosterd, Michael Beyeler

In order to improve the efficacy and safety of treatments, drug dosage needs to be adjusted to the actual needs of each patient in a truly personalized medicine approach. Key for widespread dosage adjustment is the availability of point-of-care devices abl ...

Amer Chemical Soc2015

Photodynamic induced uptake of liposomal doxorubicin to rat lung tumors parallels tumor vascular density

Hubert van den Bergh, Elodie Debefve, Laurent Décosterd

Visudyne®-mediated photodynamic therapy (PDT) at low drug/light conditions has shown to selectively enhance the uptake of liposomal doxorubicin in subpleural localized sarcoma tumors grown on rodent lungs without causing morphological alterations of the lu ...

2012

Photodynamic Therapy Selectively Enhances Liposomal Doxorubicin Uptake in Sarcoma Tumors to Rodent Lungs

Hubert van den Bergh, Georges Wagnières, Elodie Debefve, Laurent Décosterd

Background: In specific conditions, photodynamic therapy (PDT) can enhance the distribution of macromolecules across the endothelial barrier in solid tumors. It was recently postulated that tumor neovessels were more responsive to PDT than the normal vascu ...

Wiley-Blackwell2010