Publications de Loïc Dayon | EPFL Graph Search

Lactoferrin-osteopontin complexes: insights into intestinal organoid bioavailability and gut microbiota modulation

Lactoferrin (LF) and osteopontin (OPN) are key bioactive milk proteins with significant immunemodulatory, gut, and systemic health benefits. We investigated the bioavailability and intestinal uptake dynamics of bovine LF-OPN soluble complexes (SC) and comp ...

Springer Science and Business Media LLC2025

Unravelling disease complexity: integrative analysis of multi-omic data in clinical research

Loïc Dayon

Informa UK Limited2025

Analyzing Various Biological Fluids with a Single Automated Proteomic Workflow for Biomarker Discovery

Loïc Dayon

The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.Protein biomarker discovery in human biological fluids has greatly developed over the past two decades thanks to technological advances allowing deeper ...

Springer US2025

Neuropsychiatric symptoms in cognitive decline and Alzheimer's disease: biomarker discovery using plasma proteomics

Loïc Dayon

Background and objectives Neuropsychiatric symptoms (NPS) are common in older people with cognitive impairment and Alzheimer's disease (AD). No biomarkers to detect the related pathology or predict the clinical evolution of NPS are available yet. This stud ...

BMJ PUBLISHING GROUP2024

Detection of gluten peptides in human duodenal fluids with immuno-liquid chromatography-mass spectrometry

Loïc Dayon

Gluten proteins are storage proteins in wheat that exhibit a certain resistance to gastrointestinal digestion. To explore solutions to cope with accidental ingestion of gluten in individuals suffering from gluten-related disorders, it is essential to monit ...

ROYAL SOC CHEMISTRY2024

SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin-secreting cells

Loïc Dayon, Andreas Wiederkehr

Glucose sensing in pancreatic D-cells depends on oxidative phosphorylation and mitochondria-derived signals that promote insulin secretion. Using mass spectrometry-based phosphoproteo-mics to search for downstream effectors of glucose-dependent signal tran ...

COMPANY BIOLOGISTS LTD2023

Systemic and central nervous system neuroinflammatory signatures of neuropsychiatric symptoms and related cognitive decline in older people

Loïc Dayon

Background Neuroinflammation may contribute to psychiatric symptoms in older people, in particular in the context of Alzheimer's disease (AD). We sought to identify systemic and central nervous system (CNS) inflammatory alterations associated with neuropsy ...

BMC2022

Proteomics of human biological fluids for biomarker discoveries: technical advances and recent applications

Loïc Dayon

Introduction Biological fluids are routine samples for diagnostic testing and monitoring. Blood samples are typically measured because of their moderate invasive collection and high information content on health and disease. Several body fluids, such as ce ...

TAYLOR & FRANCIS LTD2022

Assessing normalization methods in mass spectrometry-based proteome profiling of clinical samples

Loïc Dayon

Background: Large-scale proteomic studies have to deal with unwanted variability, especially when samples originate from different centers and multiple analytical batches are needed. Such variability is typically added throughout all the steps of a clinica ...

ELSEVIER SCI LTD2022

The promise of multi-omics approaches to discover biological alterations with clinical relevance in Alzheimer's disease

Loïc Dayon

Beyond the core features of Alzheimer's disease (AD) pathology, i.e. amyloid pathology, tau-related neurodegeneration and microglia response, multiple other molecular alterations and pathway dysregulations have been observed in AD. Their inter-individual v ...

FRONTIERS MEDIA SA2022