Personne

Karen Cheung

Cette personne n’est plus à l’EPFL

Publications associées (8)

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We present the fabrication, characterization, use in cortical recording and histological results of a flexible implantable neural probe. The microfabricated device is implemented in polyimide and platinum providing mechanical flexibility, high quality elec ...

2008

This work presents implantable, flexible polymer-based probes with embedded microelectrodes for acute and chronic neural recordings in vivo, as tested on rodents. Acute recordings using this array were done in mice under urethane anesthesia and compared to ...

2007

BioMEMS for medicine: On-chip cell characterization and implantable microelectrodes

Philippe Renaud, Karen Cheung

This paper surveys a few of the emerging bioMEMS technologies at EPFL for improved, inexpensive health care. The lab-on-a-chip systems use dielectrophoretic forces to direct cell movement within microfluidic networks and impedance spectroscopy for label-fr ...

2006

Impedance spectroscopy flow cytometry: Parameters for label-free cell differentiation

Philippe Renaud, Shady Didier Gawad, Karen Cheung

This work presents label-free separation of cells in an on-chip flow cytometer based on impedance spectroscopy. The amplitude, opacity, and phase information can be used for discrimination depending on the cell types. Red blood cells, ghosts, and fixed cel ...

2005

Impedance spectroscopy flow cytometry: Model validation

Philippe Renaud, Shady Didier Gawad, Karen Cheung

A number of microfabricated flow cytometry devices have been proposed based on electrical(1,2) or optical(3) detection techniques. On chip marker-free differentiation of cells using impedance spectroscopy was demonstrated between leukocyte sub-populations ...

2005

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Background: The microfabricated impedance spectroscopy flow cytometer used in this study permits rapid dielectric characterization of a cell population with a simple microfluidic channel. Impedance measurements over a wide frequency range provide informati ...

2005

Dielectric spectroscopy in a micromachined flow cytometer: theoretical and practical considerations

Philippe Renaud, Arnaud Bertsch, Shady Didier Gawad, Urban Seger, Karen Cheung

We propose a model to determine the influence of different cell properties, such as size, membrane capacitance and cytoplasm conductivity, on the impedance spectrum as measured in a microfabricated cytometer. A dielectric sphere of equivalent complex permi ...

2004

Microfluidic impedance spectroscopy flow cytometer: Particle size calibration

Philippe Renaud, Shady Didier Gawad, Karen Cheung

This paper presents a microfabricated impedance spectroscopy flow cytometer which permits rapid and easy dielectric characterization of cells as they flow in a microchannel. Both a simple theoretical model and a finite element simulation show that the effe ...

2004