Publications de Michèle Koenigsberger

Mechanisms of Propagation of Intercellular Calcium Waves in Arterial Smooth Muscle Cells

Jean-Jacques Meister, Jean-Louis Bény, Dominique Seppey, Michèle Koenigsberger

In rat mesenteric arteries, smooth muscle cells exhibit intercellular calcium waves in response to local phenylephrine stimulation. These waves have a velocity of similar to 20 cells/s and a range of similar to 80 cells. We analyze these waves in a theoret ...

Elsevier2010

Intercellular calcium waves are associated with the propagation of vasomotion along arterial strips

Jean-Jacques Meister, Jean-Louis Bény, Roger Sauser, Dominique Seppey, Michèle Koenigsberger

Vasomotion consists of cyclic arterial diameter variations induced by synchronous contractions and relaxations of smooth muscle cells. However, the arteries do not contract simultaneously on macroscopic distances, and a propagation of the contraction can b ...

2010

Calcium dynamics and vasomotion in arteries subject to isometric, isobaric, and isotonic conditions

Jean-Jacques Meister, Jean-Louis Bény, Roger Sauser, Dominique Seppey, Michèle Koenigsberger

In vitro, different techniques are used to study the smooth muscle cells' calcium dynamics and contraction/relaxation mechanisms on arteries. Most experimental studies use either an isometric or an isobaric setup. However, in vivo, a blood vessel is neithe ...

2008

Does the Endothelium Abolish or Promote Arterial Vasomotion in Rat Mesenteric Arteries? Explanations for the Seemingly Contradictory Effects

Jean-Jacques Meister, Jean-Louis Bény, Roger Sauser, Dominique Seppey, Michèle Koenigsberger

Karger2008

Effects of arterial wall stress on vasomotion

Jean-Jacques Meister, Jean-Louis Bény, Roger Sauser, Michèle Koenigsberger

Smooth muscle and endothelial cells in the arterial wall are exposed to mechanical stress. Indeed blood flow induces intraluminal pressure variations and shear stress. An increase in pressure may induce a vessel contraction, a phenomenon known as the myoge ...

Elsevier2006

A theoretical model of the cellular calcium dynamics and vasomotion in muscular arteries

Michèle Koenigsberger

Muscular arteries possess the ability to control actively their lumen by altering the tone of the smooth muscle cells of the arterial wall, a property which is vital for a large number of the hemodynamical functions of the body. Arterial contraction is due ...

EPFL2006

Role of myoendothelial communication on arterial vasomotion

Jean-Louis Bény, Roger Sauser, Michèle Koenigsberger

2006

Emergent properties of electrically coupled smooth muscle cells

Jean-Jacques Meister, Roger Sauser, Michèle Koenigsberger

Asynchronous and synchronous calcium oscillations occur in a variety of cells. A well-established pathway for intercellular communication is provided by gap junctions which connect adjacent cells and can mediate electrical and chemical coupling. Several ex ...

Springer-Verlag2005

Evidence for signaling via gap junctions from smooth muscle to endothelial cells in rat mesenteric arteries: possible implication of a second messenger

Jean-Jacques Meister, Jean-Louis Bény, Roger Sauser, Michèle Koenigsberger, Philippe Pittet, Mathieu Lamboley

We investigated heterocellular communication in rat mesenteric arterial strips at the cellular level using confocal microscopy. To visualize Ca(2+) changes in different cell populations, smooth muscle cells (SMCs) were loaded with Fluo-4 and endothelial ce ...

Elsevier2005

Role of the Endothelium on Arterial Vasomotion

Michèle Koenigsberger

Elsevier2005