Publications de Stefano Tugulu

Sediment traps with guiding channel and hybrid check dams improve controlled sediment retention

Mário Jorge Rodrigues Pereira Da Franca, Sebastian Schwindt, Stefano Tugulu, Alessandro Reffo

Sediment traps with partially open check dams are crucial elements for flood protection in alpine regions. The trapping of sediment is necessary when intense sediment transport occurs during floods that may endanger urban areas at downstream river reaches. ...

2018

Polymer Brushes via Surface-Initiated Controlled Radical Polymerization: Synthesis, Characterization, Properties, and Applications

Harm-Anton Klok, Stefano Tugulu, Raphaël Barbey, Caroline Sugnaux, Dusko Paripovic, Nicolas Bertrand Schüwer

American Chemical Society2009

Surface Modification of Polydimethylsiloxane Substrates with Nonfouling Poly(Poly(ethylene glycol)methacrylate) Brushes

Harm-Anton Klok, Stefano Tugulu

This contribution presents a new strategy to grow nonfouling poly (poly(ethylene glycol) methacrylate) (PPEGMA) brushes from polydimethylsiloxane (PDMS) substrates. The strategy presented here is based on the use of a sequence of vapor deposition/hydrolysi ...

2009

Stability and nonfouling properties of poly(poly(ethylene glycol) methacrylate) brushes under cell culture conditions

Harm-Anton Klok, Stefano Tugulu

American Chemical Society2008

Functional polymer brushes via surface-initiated controlled radical polymerizations

Stefano Tugulu

The term polymer brush refers to a well defined arrangement of polymer chains, which are tethered with one end to an interface and usually the surface of a solid substrate. Due to steric repulsion the polymer chains furthermore adopt a defined, stretched c ...

EPFL2007

RGD-Functionalized polymer brushes as substrates for the integrin specific adhesion of human umbilical vein endothelial cells

Nikolaos Stergiopoulos, Harm-Anton Klok, Paolo Silacci, Stefano Tugulu

This report demonstrates the feasibility of surface-initiated atom transfer radical polymerization to prepare thin polymer layers ("brushes") that can be functionalized with short peptide ligands and which may be of use as coatings to promote endothelializ ...

2007

Synthesis of poly(methacrylic acid) brushes via surface-initiated atom transfer radical polymerization of sodium methacrylate and their use as substrates for the mineralization of calcium carbonate

Harm-Anton Klok, Stefano Tugulu, Raphaël Barbey

This manuscript describes the synthesis of poly(methacrylic acid) (PMAA) brushes via surface-initiated atom transfer radical polymerization (SI-ATRP) of sodium methacrylate (NaMA) and their use as substrates for the mineralization of calcium carbonate. A C ...

American Chemical Society2007

Protein function microarrays based on self-immobilizing and self-labeling fusion proteins

Harm-Anton Klok, Kai Johnsson, Stefano Tugulu, India Christina Sielaff, Anke Arnold

Protein microarrays are an attractive approach for the high-throughput analysis of protein function, but their impact on proteomics has been limited by the technical difficulties associated with their generation. Here we demonstrate that fusion proteins of ...

2006

Protein-functionalized polymer brushes

Kai Johnsson, Harm-Anton Klok, Anke Arnold, Stefano Tugulu, India Christina Sielaff

Understanding and controlling the interactions between synthetic and biol. materials is of great importance for the development of novel materials for a variety of biomedical and bioanal. applications, including for example stents, vascular grafts and prot ...

2005

Protein-Functionalized Polymer Brushes

Harm-Anton Klok, Kai Johnsson, Stefano Tugulu, India Christina Sielaff, Anke Arnold

A new strategy for the prepn. of protein-functionalized polymer brushes is reported, which is based on a combination of surface-initiated atom transfer radical polymn. (ATRP), p-nitrophenyl chloroformate activation of the surface hydroxyl groups, and subse ...

American Chemical Society2005