Luca Dede'

Cette personne n’est plus à l’EPFL

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Publications associées (37)

An image-based computational hemodynamics study of the Systolic Anterior Motion of the mitral valve

Alfio Quarteroni, Luca Dede', Christian Vergara, Marco Fedele

Systolic Anterior Motion (SAM) of the mitral valve - often associated with Hypertrophic Obstructive Cardiomyopathy (HOCM) - is a cardiac pathology in which a functional subaortic stenosis is induced during systole by the mitral leaflets partially obstructi ...

PERGAMON-ELSEVIER SCIENCE LTD2020

Outer loop and isthmus in ventricular tachycardia circuits: Characteristics and implications

Alfio Quarteroni, Andrea Manzoni, Luca Dede', Stefano Pagani

BACKGROUND The isthmus of ventricular tachycardia (VT) circuits has been extensively characterized. Few data exist regarding the contribution of the outer loop (OL) to the VT circuit. OBJECTIVE The purpose of this study was to characterize the electrophysi ...

2020

Deep learning-based reduced order models in cardiac electrophysiology

Alfio Quarteroni, Andrea Manzoni, Luca Dede'

Predicting the electrical behavior of the heart, from the cellular scale to the tissue level, relies on the numerical approximation of coupled nonlinear dynamical systems. These systems describe the cardiac action potential, that is the polarization/depola ...

2020

Isogeometric Analysis of the electrophysiology in the human heart: Numerical simulation of the bidomain equations on the atria

Alfio Quarteroni, Luca Dede', Luca Pegolotti

We consider Isogeometric Analysis (IGA) for the numerical solution of the electrophysiology of the atria, which in this work is modeled by means of the bidomain equations on thin surfaces. First, we consider the bidomain equations coupled with the Roger-Mc ...

ELSEVIER SCIENCE SA2019

Biomembrane modeling with isogeometric analysis

Alfio Quarteroni, Luca Dede', Andrea Bartezzaghi

We consider the numerical approximation of lipid biomembranes at equilibrium described by the Canham-Helfrich model, according to which the bending energy is minimized under area and volume constraints. Energy minimization is performed via L-2-gradient flo ...

ELSEVIER SCIENCE SA2019

A transmurally heterogeneous orthotropic activation model for ventricular contraction and its numerical validation

Alfio Quarteroni, Luca Dede', Simone Rossi, Luca Barbarotta

Models for cardiac mechanics require an activation mechanism properly representing the stress-strain relations in the contracting myocardium. In this paper, we propose a new activation model that accounts for the transmural heterogeneities observed in myoc ...

Wiley2018

Active contraction of cardiac cells: a reduced model for sarcomere dynamics with cooperative interactions

Alfio Quarteroni, Luca Dede', Francesco Regazzoni

We propose a reduced ODE model for the mechanical activation of cardiac myofilaments, which is based on explicit spatial representation of nearest-neighbour interactions. Our model is derived from the cooperative Markov Chain model of Washio et al. (Cell M ...

SPRINGER HEIDELBERG2018

A monolithic algorithm for the simulation of cardiac electromechanics in the human left ventricle

Alfio Quarteroni, Luca Dede', Antonello Gerbi

In this paper, we propose a monolithic algorithm for the numerical solution of the electromechanics model of the left ventricle in the human heart. Our coupled model integrates the monodomain equation with the Bueno-Orovio minimal model for electrophysiolo ...

2018

Isogeometric analysis and proper orthogonal decomposition for parabolic problems

Alfio Quarteroni, Luca Dede', Shengfeng Zhu

We investigate the combination of Isogeometric Analysis (IGA) and proper orthogonal decomposition (POD) based on the Galerkin method for model order reduction of linear parabolic partial differential equations. For the proposed fully discrete scheme, the a ...

Springer2017

Isogeometric approximation of cardiac electrophysiology models on surfaces: An accuracy study with application to the human left atrium

Alfio Quarteroni, Luca Dede', Toni Mikael Lassila, Alessandro Samuele Patelli, Andrea Bartezzaghi

We consider Isogeometric Analysis in the framework of the Galerkin method for the spatial approximation of cardiac electrophysiology models defined on NURBS surfaces; specifically, we perform a numerical comparison between basis functions of degree p >= 1 ...

Elsevier2017

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Isogeometric Analysis of the electrophysiology in the human heart: Numerical simulation of the bidomain equations on the atria

Alfio Quarteroni, Luca Dede', Luca Pegolotti

ELSEVIER SCIENCE SA2019

Isogeometric approximation of cardiac electrophysiology models on surfaces: An accuracy study with application to the human left atrium

Alfio Quarteroni, Luca Dede', Toni Mikael Lassila, Alessandro Samuele Patelli, Andrea Bartezzaghi

Elsevier2017