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Synaptically released glutamate has been identified as a signal coupling excitatory neuronal activity to increased glucose utilization. The proposed mechanism of this coupling involves glutamate uptake into astrocytes resulting in increased intracellular N ...
The effects of inhibitors of the glial Na+/glutamate co-transporter on the intracellular Na+ concentration (Na+) were investigated in mouse cortical astrocytes. Na+ was monitored by fluorescence microscopy on single astrocytes using the Na+-sensi ...
Therapeutic value of the alkylating agent ifosfamide has been limited by major side effects including encephalopathy. Although the underlying biochemical processes of the neurotoxic side effects are still unclear, they could be attributed to metabolites ra ...
The mode of Na+ entry and the dynamics of intracellular Na+ concentration ([Na+]i) changes consecutive to the application of the neurotransmitter glutamate were investigated in mouse cortical astrocytes in primary culture by video fluorescence microscopy. ...
