Publications de Graham Knott | EPFL Graph Search

Synaptic proximity enables NMDAR signalling to promote brain metastasis

Graham Knott, Douglas Hanahan, Brian Donal McCabe, Mohammad Sadegh Saghafinia, Inti Zlobec, Iacovos Michael, Qiqun Zeng, Wei Jiao, Giovanni Ciriello, Peng Zhang

Metastasis-the disseminated growth of tumours in distant organs-underlies cancer mortality. Breast-to-brain metastasis (B2BM) is a common and disruptive form of cancer and is prevalent in the aggressive basal-like subtype, but is also found at varying freq ...

2019

Diversity of Cortico-descending Projections: Histological and Diffusion MRI Characterization in the Monkey

Jean-Philippe Thiran, Graham Knott, Maxime Descoteaux, Giorgio Innocenti, Tim Bjørn Dyrby

The axonal composition of cortical projections originating in premotor, supplementary motor (SMA), primary motor (a4), somatosensory and parietal areas and descending towards the brain stem and spinal cord was characterized in the monkey with histological ...

OXFORD UNIV PRESS INC2019

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

Johan Auwerx, Kristina Schoonjans, Bernard Schneider, Graham Knott, Davide D'Amico, Vera Monica Lemos Da Silva, Mario Romani, Hao Li, Vincenzo Sorrentino, Adrienne Joëlle Laurence Mottis, Francesca Potenza

Little information is available about how post-transcriptional mechanisms regulate the aging process. Here, we show that the RNA-binding protein Pumilio2 (PUM2), which is a translation repressor, is induced upon aging and acts as a negative regulator of li ...

CELL PRESS2019

Probabilistic Atlases to Enforce Topological Constraints

Pascal Fua, Graham Knott, Pamuditha Udaranga Wickramasinghe

Probabilistic atlases (PAs) have long been used in standard segmentation approaches and, more recently, in conjunction with Convolutional Neural Networks (CNNs). However, their use has been restricted to relatively standardized structures such as the brain ...

2019

Cellular Uptake and Intracellular Trafficking of Poly(N-(2-Hydroxypropyl) Methacrylamide)

Anders Meibom, Harm-Anton Klok, Graham Knott, Stéphane Laurent Escrig, Olivier Burri, Arne Seitz, Romain Guiet, Claudia Battistella

Cellular uptake and intracellular trafficking of polymer conjugates or polymer nanoparticles is typically monitored using fluorescence-based techniques such as confocal microscopy. While these methods have provided a wealth of insight into the internalizat ...

2019

Locally coordinated synaptic plasticity of visual cortex neurons in vivo

Graham Knott, Sami El-Boustani

Plasticity of cortical responses in vivo involves activity-dependent changes at synapses, but the manner in which different forms of synaptic plasticity act together to create functional changes in neurons remains unknown. We found that spike timing-induce ...

AMER ASSOC ADVANCEMENT SCIENCE2018

Ultrastructural basis of strong unitary inhibition in a binaural neuron

Graham Knott, Ralf Schneggenburger, Enida Gjoni, Clémentine Léa Aguet

Binaural neurons in the lateral superior olive (LSO) integrate sound information arriving from each ear, and powerful glycinergic inhibition of these neurons plays an important role in this process. In the present study, we investigated the ultrastructural ...

WILEY2018

Molecular insights into Vibrio cholerae’s intra-amoebal host-pathogen interactions

Graham Knott, Melanie Blokesch, Sandrine Stutzmann, Candice Stoudmann, Catherine Maclachlan, Natalia Carolina Drebes Dorr, Tiziana Scrignari, Charles Ulric V Van der Henst, Audrey Sophie Vanhove

Vibrio cholerae, which causes the diarrheal disease cholera, is a species of bacteria commonlyfound in aquatic habitats. Within such environments, the bacterium must defend itselfagainst predatory protozoan grazers. Amoebae are prominent grazers, withAcant ...

2018

Chattez avec Graph Search

Posez n’importe quelle question sur les cours, conférences, exercices, recherches, actualités, etc. de l’EPFL ou essayez les exemples de questions ci-dessous.

AVERTISSEMENT : Le chatbot Graph n'est pas programmé pour fournir des réponses explicites ou catégoriques à vos questions. Il transforme plutôt vos questions en demandes API qui sont distribuées aux différents services informatiques officiellement administrés par l'EPFL. Son but est uniquement de collecter et de recommander des références pertinentes à des contenus que vous pouvez explorer pour vous aider à répondre à vos questions.

Graham Knott

Synaptic proximity enables NMDAR signalling to promote brain metastasis

Diversity of Cortico-descending Projections: Histological and Diffusion MRI Characterization in the Monkey

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

Probabilistic Atlases to Enforce Topological Constraints

Cellular Uptake and Intracellular Trafficking of Poly(N-(2-Hydroxypropyl) Methacrylamide)

Locally coordinated synaptic plasticity of visual cortex neurons in vivo

Ultrastructural basis of strong unitary inhibition in a binaural neuron

Molecular insights into Vibrio cholerae’s intra-amoebal host-pathogen interactions

Amygdala GluN2B-NMDAR dysfunction is critical in abnormal aggression of neurodevelopmental origin induced by St8sia2 deficiency

Graph Chatbot

Chattez avec Graph Search

Ultrastructural basis of strong unitary inhibition in a binaural neuron

Probabilistic Atlases to Enforce Topological Constraints

Molecular insights into Vibrio cholerae’s intra-amoebal host-pathogen interactions

Amygdala GluN2B-NMDAR dysfunction is critical in abnormal aggression of neurodevelopmental origin induced by St8sia2 deficiency

Synaptic proximity enables NMDAR signalling to promote brain metastasis

Diversity of Cortico-descending Projections: Histological and Diffusion MRI Characterization in the Monkey

Cellular Uptake and Intracellular Trafficking of Poly(N-(2-Hydroxypropyl) Methacrylamide)

Locally coordinated synaptic plasticity of visual cortex neurons in vivo

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging