Publications de Maria del Carmen Sandi Perez

Corticotropin-releasing hormone modulates NREM sleep consolidation through the thalamic reticular nucleus

Maria del Carmen Sandi Perez, Olivia Zanoletti, Simone Astori

Corticotropin-releasing hormone (CRH) is a peptide associated with stress and anxiety that acts as a potent modulator throughout the nervous system. The thalamic reticular nucleus (TRN) displays high expression of the CRH receptor 1 (CRHR1), but whether CR ...

Springer Science and Business Media LLC2025

Neural markers of social dominance: A female-focused perspective

Michael Herzog, Maria del Carmen Sandi Perez, Janir Nuno Ramos Antunes Da Cruz, Wei-Hsiang Lin

Social interactions are fundamental to human life, with social dominance being a key factor in these interactions. Previous studies have shown that dominant males are faster in decision-making tasks compared to non-dominant ones, even in the absence of a s ...

Elsevier BV2025

Embracing the Modern Biochemistry of Brain Metabolism

Maria del Carmen Sandi Perez

This editorial challenges the long‐held neuron‐centered view of brain metabolism, relying on ample evidence that it is a cooperative, multicellular process. Astrocytes, oligodendrocytes, and other glia play active roles providing lactate, antioxidant suppo ...

Wiley2025

Mitochondrial control of ciliary gene expression and structure in striatal neurons

Maria del Carmen Sandi Perez, Olivia Zanoletti, Dogukan Hazar Ülgen, Alessandro Chioino

Mitochondria play essential metabolic roles and are increasingly understood to interact with other organelles, influencing cellular function and disease. Primary cilia, as sensory and signalling organelles, are crucial for neuronal communication and functi ...

WILEY2025

Heterozygous females from a rat model for creatine transporter deficiency reveal altered behavioral response to stressors, normal body weight and slight metabolic changes

Maria del Carmen Sandi Perez, Cristina Ramona Cudalbu, Dunja Simicic

Creatine (Cr) is an organic acid essential for recycling ATP, important in tissues with high energy demand such as muscle or brain. Cr is synthesized in a 2-step pathway by the enzymes AGAT and GAMT, and transported by SLC6A8 (also called CrT). Cerebral Cr ...

2025

Urolithin A abolishes high anxiety and rescues the associated mitochondria-related transcriptomic signatures and synaptic function

Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Davide D'Amico, Simone Astori, Marie-Isabelle Guillot de Suduiraut, Dogukan Hazar Ülgen

Background: Chronic anxiety is common, disabling, and often refractory to current therapies. Mounting evidence implicates mitochondrial abnormalities in anxiety-related phenotypes. Urolithin A (UA), a gut microbiota-derived metabolite known to enhance mito ...

Elsevier BV2025

Long term effects of peripubertal stress on the thalamic reticular nucleus of female and male mice

Maria del Carmen Sandi Perez

Adverse experiences during infancy and adolescence have an important and enduring effect on the brain and are predisposing factors for mental disorders, particularly major depression. This impact is particularly notable in regions with protracted developme ...

Elsevier BV2024

Rescue of myocytes and locomotion through AAV2/9-2YF intracisternal gene therapy in a rat model of creatine transporter deficiency

Maria del Carmen Sandi Perez, Cristina Ramona Cudalbu

Creatine de fi ciency syndromes (CDS), caused by mutations in GATM (AGAT), GAMT , and SLC6A8 , mainly affect the central nervous system (CNS). CDS show brain creatine (Cr) de fi ciency, intellectual disability with severe speech delay, behavioral troubles, ...

Cell Press2024

Dopamine dynamics in nucleus accumbens across reward-based learning of goal-directed whisker-to-lick sensorimotor transformations in mice

Maria del Carmen Sandi Perez, Carl Petersen, Sylvain Crochet, Jun Huang

The synaptic and neuronal circuit mechanisms underlying reward-based learning remain to be fully determined. In the mammalian brain, dopamine release in nucleus accumbens is thought to contribute importantly to reward signals for learning and promoting syn ...

Elsevier BV2024

A neurometabolic mechanism involving dmPFC/dACC lactate in physical effort-based decision-making

Maria del Carmen Sandi Perez, Lijing Xin, Nicolas Clairis, Arthur Barakat

Motivation levels vary across individuals, yet the underlying mechanisms driving these differences remain elusive. The dorsomedial prefrontal cortex/dorsal anterior cingulate cortex (dmPFC/dACC) and the anterior insula (aIns) play crucial roles in effort-b ...

Springer Science and Business Media LLC2024