Publications de Thomas Schaffter

From Genes to Organisms : Bioinformatics System Models and Software

The expression of genes is controlled by regulatory networks, which performspecific functions in a cell. Gene networks play a crucial role in the development of multicellular organisms by precisely coordinating spatial and temporal gene expression patterns ...

EPFL2014

Fluorescence Behavioral Imaging (FBI) tracks identity in heterogeneous groups of Drosophila

Dario Floreano, Pavan P Ramdya, Thomas Schaffter

Distinguishing subpopulations in group behavioral experiments can reveal the impact of differences in genetic, pharmacological and life-histories on social interactions and decision-making. Here we describe Fluorescence Behavioral Imaging (FBI), a toolkit ...

2012

GeneNetWeaver: In silico benchmark generation and performance profiling of network inference methods

Dario Floreano, Daniel Marbach, Thomas Schaffter

Motivation: Over the last decade, numerous methods have been developed for inference of regulatory networks from gene expression data. However, accurate and systematic evaluation of these methods is hampered by the difficulty of constructing adequate bench ...

Oxford University Press2011

Generating Realistic In Silico Gene Networks for Performance Assessment of Reverse Engineering Methods

Dario Floreano, Claudio Mattiussi, Daniel Marbach, Thomas Schaffter

Reverse engineering methods are typically first tested on simulated data from in silico networks, for systematic and efficient performance assessment, before an application to real biological networks. In this paper we present a method for generating biolo ...

2009