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Thomas Schaffter

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Publications associées (9)

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Fluorescence Behavioral Imaging (FBI) tracks identity in heterogeneous groups of Drosophila

Dario Floreano, Pavan P Ramdya, Thomas Schaffter

Distinguishing subpopulations in group behavioral experiments can reveal the impact of differences in genetic, pharmacological and life-histories on social interactions and decision-making. Here we describe Fluorescence Behavioral Imaging (FBI), a toolkit ...

2012

GeneNetWeaver: In silico benchmark generation and performance profiling of network inference methods

Dario Floreano, Daniel Marbach, Thomas Schaffter

Motivation: Over the last decade, numerous methods have been developed for inference of regulatory networks from gene expression data. However, accurate and systematic evaluation of these methods is hampered by the difficulty of constructing adequate bench ...

Oxford University Press2011

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Numerous methods have been developed for inference of gene regulatory networks from expression data, however, their strengths and weaknesses remain poorly understood. Accurate and systematic evaluation of these methods is hampered by the difficulty of cons ...

2010

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2010

Revealing strengths and weaknesses of methods for gene network inference

Dario Floreano, Claudio Mattiussi, Daniel Marbach, Thomas Schaffter

Numerous methods have been developed for inferring gene regulatory networks from expression data, however, both their absolute and comparative performance remain poorly understood. In this paper, we introduce a framework for critical performance assessment ...

2010

Introduction to numerical methods to simulate systems of stochastic differential equations (SDEs) both in Ito and Stratonovich scheme. ...

2010

Generating Realistic In Silico Gene Networks for Performance Assessment of Reverse Engineering Methods

Dario Floreano, Claudio Mattiussi, Daniel Marbach, Thomas Schaffter

Reverse engineering methods are typically first tested on simulated data from in silico networks, for systematic and efficient performance assessment, before an application to real biological networks. In this paper we present a method for generating biolo ...

2009

Scalable Reverse Engineering of Nonlinear Gene Networks

Dario Floreano, Claudio Mattiussi, Daniel Marbach, Thomas Schaffter

Current advanced molecular biology techniques provide gene expression (mRNA) levels of selected genes of an organism. In such aggregate, the mRNA level of one gene is mediated by the presence of specific proteins and metabolites produced by other genes. Ge ...

2008

On s'applique ici à étudier et caractériser les Algorithmes Génétiques (AG) qui appartiennent à la famille des algorithmes évolutionnaires. L'objectif de ce projet est de mettre en place un programme permettant d'optimiser un système réel tel qu'un moteur ...

2007