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Highly Integrated Multi-Material Fibers for Soft Robotics

Hritwick Banerjee, Nicola Bartolomei, Chaoqun Dong, Stella Andréa Françoise Laperrousaz, Andreas Leber, Bastien Schyrr, Fabien Sorin

Soft robots are envisioned as the next generation of safe biomedical devices in minimally invasive procedures. Yet, the difficulty of processing soft materials currently limits the size, aspect-ratio, manufacturing throughput, as well as, the design complexity and hence capabilities of soft robots. Multi-material thermal drawing is introduced as a material and processing platform to create soft robotic fibers imparted with multiple actuations and sensing modalities. Several thermoplastic and elastomeric material options for the fibers are presented, which all exhibit the rheological processing attributes for thermal drawing but varying mechanical properties, resulting in adaptable actuation performance. Moreover, numerous different fiber designs with intricate internal architectures, outer diameters of 700 mu m, aspect ratios of 10(3), and a fabrication at a scale of 10s of meters of length are demonstrated. A modular tendon-driven mechanism enables 3-dimensional (3D) motion, and embedded optical guides, electrical wires, and microfluidic channels give rise to multifunctionality. The fibers can perceive and autonomously adapt to their environments, as well as, probe electrical properties, and deliver fluids and mechanical tools to spatially distributed targets.

WILEY2022

Self-Assembled Dewetting as a Fabrication Platform for Photonics Applications

William Nicolas Duncan Esposito, Louis Marie Philippe Martin-Monier, Pierre-Luc Eloi Piveteau, Bastien Schyrr, Fabien Sorin

A novel fabrication method based on controlled fluid re-arrangement of thin amorphous optical glass film is leveraged to realize two large-area photonics metasurfaces: 1) a highly directional nanoantenna array (metareflector), and 2) a metagrating for index sensing. (C) 2022 The Author(s)

IEEE2022

Nanoparticle based Tuberculosis vaccine

Bastien Schyrr

Despite the widespread use of Bacille de Calmette et Guérin (BCG) for over50 years, tuberculosis (TB) continues to be a major global health problem, especially in developing countries. Indeed BCG as been shown to reduce infant mortality, but demonstrated very high variability in preventing TB in adults. There is thus an urgent need for the development of an e-cacious novel TB vaccine that confirms long-term protection in both adult and children. A newnanoparticle (NP) delivery technology was recently developed in the laboratories of Prof. Swartz and Prof. Hubbell at the Swiss Federal Institute of Technology in Lausanne (EPFL) which proposes an innovative gene delivery approach for immunotherapy by targeting lymph node-residing dendritic cells (DCs). The NP platform has been shown to be extremely stable, safe, cheap, and able to induce strong T-cell responses and is thus expected to be a potential candidate for BCG replacement or BCG-prime booster. In this context we describe a preclinical testing plan that includes best formulation selection, dosage determination, e--cacy, and safety testing. We also explore regulatory issues, vaccine manufactory and the transition to clinical trials. Parralelly, better characterization of the NP platform itself is needed. The second part of this project is thus devoted to the study of NP surface modifications and their implications in the genera-tion of an immune response. Experiments using methoxylated and hydroxylated NPs suggest that free thiols present at the surface play a role in complement activation, however still poorly understood. In addition, N-terminal modified thiol-containing proteins have been synthesized for coupling on pyridyldisulfide NPs. This strategy greatly broadens the application of the NP platform, since it may be applied to almost any proteins. Finally thiol caging is reported as a method to recover thiols after antigen conjugation

2008