Rolf Gruetter

Biographie

Awards:

1999 Young Investigator Award Plenary Lectureship , International Society for Neurochemistry

2011 Fellow , ESMRMB

2011 Teaching Award , Section Sciences de la Vie, EPFL

Official source

https://people.epfl.ch/rolf.gruetter?lang=fr

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Domaines de recherche associés (89)

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Publications associées (599)

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Personnes menant des recherches similaires (92)

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[13C]bicarbonate labelled from hyperpolarized [1-13C]pyruvate is an in vivo marker of hepatic gluconeogenesis in fasted state

Josefina Adriana Maria Bastiaansen, Emine Can, Arnaud Comment, Rolf Gruetter, Hikari Ananda Infinity Yoshihara

Hyperpolarized [1-13C]pyruvate enables direct in vivo assessment of real-time liver enzymatic activities by 13C magnetic resonance. However, the technique usually requires the injection of a highly supraphysiological dose of pyruvate. We herein demonstrate that liver metabolism can be measured in vivo with hyperpolarized [1-13C]pyruvate administered at two- to three-fold the basal plasma concentration. The flux through pyruvate dehydrogenase, assessed by 13C-labeling of bicarbonate in the fed condition, was found to be saturated or partially inhibited by supraphysiological doses of hyperpolarized [1-13C]pyruvate. The [13C]bicarbonate signal detected in the liver of fasted rats nearly vanished after treatment with a phosphoenolpyruvate carboxykinase (PEPCK) inhibitor, indicating that the signal originates from the flux through PEPCK. In addition, the normalized [13C]bicarbonate signal in fasted untreated animals is dose independent across a 10-fold range, highlighting that PEPCK and pyruvate carboxylase are not saturated and that hepatic gluconeogenesis can be directly probed in vivo with hyperpolarized [1-13C]pyruvate.

2022

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Purpose: Simultaneous scalp electroencephalography and functional magnetic resonance imaging (EEG-fMRI) enable noninvasive assessment of brain function with high spatial and temporal resolution. However, at ultra-high field, the data quality of both modalities is degraded by mutual interactions. Here, we thoroughly investigated the radiofrequency (RF) shielding artifact of a state-of-the-art EEG-fMRI setup, at 7 T, and design a practical solution to limit this issue. Methods: Electromagnetic field simulations and MR measurements assessed the shielding effect of the EEG setup, more specifically the EEG wiring. The effectiveness of segmenting the wiring with resistors to reduce the transmit field disruption was evaluated on a wire-only EEG model and a simulation model of the EEG cap. Results: The EEG wiring was found to exert a dominant effect on the disruption of the transmit field, whose intensity varied periodically as a function of the wire length. Breaking the electrical continuity of the EEG wires into segments shorter than one quarter RF wavelength in air (25 cm at 7 T) reduced significantly the RF shielding artifacts. Simulations of the EEG cap with segmented wires indicated similar improvements for a moderate increase of the power deposition. Conclusion: We demonstrated that segmenting the EEG wiring into shorter lengths using commercially available nonmagnetic resistors is effective at reducing RF shielding artifacts in simultaneous EEG-fMRI. This prevents the formation of RF-induced standing waves, without substantial specific absorption rate (SAR) penalties, and thereby enables benefiting from the functional sensitivity boosts achievable at ultra-high field.

2022

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Shortened dipole antennas based on rectangular dielectric blocks play an important role in ultrahigh field magnetic resonance imaging (UHF-MRI) radio frequency (RF) coil design. However, the generally assumed direct contact with the subject is difficult to maintain in typical in vivo settings. We have previously observed that certain dielectrically shortened dipole antennas can produce a substantially altered transmit field distribution with a very low transmit efficiency when the block and the sample are physically separated. Therefore, the aim of this study was to determine a) why certain designs of dielectrically shortened dipole antennas can produce an inefficient transmit field when the block and the sample are physically separated and b) how this depends on key parameters such as rectangular block geometry, dielectric constant, loading geometry, and RF feeding. In this work, two main types of quasi-transverse dielectric modes were found in different rectangular block geometries and interpreted as TE11 delta z (MR efficient) and TE1 delta delta y (MR inefficient), and their impact on in vivo MRI experiments involving the human head, calf, and wrist was explored. This study shows, for the first time, why certain antennas preserve their transmit field efficiency despite physical separation from the sample. We conclude that the proposed approach has the potential to provide new insights into dipole antenna design for UHF-MRI.

2021

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