Publications de Sandrine Lefort

Layer-Dependent Short-Term Synaptic Plasticity Between Excitatory Neurons in the C2 Barrel Column of Mouse Primary Somatosensory Cortex

Neurons process information through spatiotemporal integration of synaptic input. Synaptic transmission between any given pair of neurons is typically a dynamic process with presynaptic action potentials (APs) evoking depressing or facilitating postsynapti ...

Oxford Univ Press Inc2017

The Excitatory Neuronal Network of the C2 Barrel Column in Mouse Primary Somatosensory Cortex

Carl Petersen, Juan-Carlos Sarria, Sandrine Lefort, Christian Tomm

Local microcircuits within neocortical columns form key determinants of sensory processing. Here, we investigate the excitatory synaptic neuronal network of an anatomically defined cortical column, the C2 barrel column of mouse primary somatosensory cortex ...

2009

Extracting non-linear integrate-and-fire models from experimental data using dynamic I – V curves

Wulfram Gerstner, Carl Petersen, Laurent Badel, Thomas Berger, Sandrine Lefort

The dynamic I–V curve method was recently introduced for the efficient experimental generation of reduced neuron models. The method extracts the response properties of a neuron while it is subject to a naturalistic stimulus that mimics in vivo-like fluctua ...

Springer Verlag2008

The excitatory neuronal microcircuit of the C2 column in the mouse primary somatosensory cortex

Sandrine Lefort

Rodents are nocturnal animals gathering information about their surroundings by using highly sensitive detectors laid out on their snout. Like humans use their fingertips to apprehend textures, rodents use their whiskers to build a spatial representation o ...

EPFL2008

Dynamic I-V curves are reliable predictors of naturalistic pyramidal-neuron voltage traces

Wulfram Gerstner, Carl Petersen, Laurent Badel, Sandrine Lefort, Romain Brette

Neuronal response properties are typically probed by intracellular measurements of current-voltage (I-V) relationships during application of current or voltage steps. Here we demonstrate the measurement of a novel I-V curve measured while the neuron exhibi ...

American Physiological Society2008

Combined voltage and calcium epifluorescence imaging in vitro and in vivo reveals subthreshold and suprathreshold dynamics of mouse barrel cortex

Carl Petersen, Sylvain Crochet, Sandrine Lefort, Thomas Berger

Cortical dynamics can be imaged at high spatiotemporal resolution with voltage-sensitive dyes (VSDs) and calcium-sensitive dyes (CaSDs). We combined these two imaging techniques using epifluorescence optics together with whole cell recordings to measure th ...

2007