Publications de Kamila Markram

Individual differences in sensory sensitivity: Further lessons from an Autism model

Henry Markram, Kamila Markram, Mônica Regina Favre

In this commentary, we join Ward (this issue) in the usefulness of conceptualizing neural output in terms of signal and noise relationships, to create the missing links between neural, behavioral and subjective sensory sensitivity. We draw from our work in ...

ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD2019

Predictable enriched environment prevents development of hyper-emotionality in the VPA rat model of autism

Henry Markram, Julie Meystre, Deborah La Mendola, Kamila Markram, Mônica Regina Favre, Melissa Cochrane, Dimitri Marco Christodoulou

Understanding the effects of environmental stimulation in autism can improve therapeutic interventions against debilitating sensory overload, social withdrawal, fear and anxiety. Here, we evaluate the role of environmental predictability on behavior and pr ...

Frontiers Research Foundation2015

Nlgn4 knockout induces network hypo-excitability in juvenile mouse somatosensory cortex in vitro

Henry Markram, Vincent Delattre, Kamila Markram, Julie Meystre, Deborah La Mendola

Neuroligins (Nlgns) are postsynaptic cell adhesion molecules that form transynaptic complexes with presynaptic neurexins and regulate synapse maturation and plasticity. We studied the impact of the loss of Nlgn4 on the excitatory and inhibitory circuits in ...

Nature Publishing Group2013

General developmental health in the VPA-rat model of autism

Henry Markram, Kamila Markram, Georges Khazen, Mônica Regina Favre

Autism is a neurodevelopmental condition diagnosed by impaired social interaction, abnormal communication and, stereotyped behaviors. While post-mortem and imaging studies have provided good insights into the neurobiological symptomology of autism, animal ...

Frontiers Research Foundation2013

Role of NCAM in emotion and learning

Maria del Carmen Sandi Perez, Kamila Markram, Reto Bisaz, Lisa Conboy

NCAM is an abundant cell adhesion molecule known to be important during development. Together with its posttranslational modification consisting of the addition of the polysaccharide polysialic acid (PSA), NCAM has been classically implicated in the regula ...

2010

The intense world theory - a unifying theory of the neurobiology of autism

Henry Markram, Kamila Markram

Autism covers a wide spectrum of disorders for which there are many views, hypotheses and theories. Here we propose a unifying theory of autism, the Intense World Theory. The proposed neuropathology is hyper-functioning of local neural microcircuits, best ...

2010

Enhanced long-term microcircuit plasticity in the valproic Acid animal model of autism

Henry Markram, Kamila Markram, Tania Rinaldi, Jean-Vincent Le Bé, Imad Riachi, Guilherme Silva

A single intra-peritoneal injection of valproic acid (VPA) on embryonic day (ED) 11.5 to pregnant rats has been shown to produce severe autistic-like symptoms in the offspring. Previous studies showed that the microcircuitry is hyperreactive due to hyperco ...

2009

Abnormal fear conditioning and amygdala processing in an animal model of autism

Maria del Carmen Sandi Perez, Henry Markram, Deborah La Mendola, Kamila Markram, Tania Rinaldi

A core feature of autism spectrum disorders is the impairment in social interactions. Among other brain regions, a deficit in amygdala processing has been suggested to underlie this impairment, but whether the amygdala is processing fear abnormally in auti ...

Nature Publishing Group2008

The role of the amygdala in emotional memories : a multidisciplinary approach

Maria del Carmen Sandi Perez, Kamila Markram

This thesis investigates the role of the amygdala for the establishment of fear memories with a multidisciplinary approach, including behavioural, psychopharmacological, genetic, molecular, and electrophysiological techniques in rats or mice, under healthy ...

EPFL2007

The intense world syndrome – an alternative hypothesis for autism

Henry Markram, Kamila Markram, Tania Rinaldi

Autism is a devastating neurodevelopmental disorder with a polygenetic predisposition that seems to be triggered by multiple environmental factors during embryonic and/or early postnatal life. While significant advances have been made in identifying the ne ...

2007