Publications de Guy Vergères | EPFL Graph Search

Inflammatory and metabolic responses to high-fat meals with and without dairy products in men

Postprandial inflammation is an important factor for human health since chronic low-grade inflammation is associated with chronic diseases. Dairy products have a weak but significant anti-inflammatory effect on postprandial inflammation. The objective of t ...

Cambridge University Press2015

Microfluidic chip for monitoring Ca2+ transport through a confluent layer of intestinal cells

Martinus Gijs, Paolo Silacci, Hüseyin Cumhur Tekin, Josias Basil Wacker, Christine Ruffert, Guy Vergères

The absorption of dietary calcium through the intestinal barrier is essential for maintaining health in general and especially of the bone system. We propose a microfluidic model that studies free calcium (Ca2+) transport through a confluent monolayer of C ...

Royal Soc Chemistry2014

Quantitative Estimation of Biological Cell Surface Receptors by Segmenting Conventional Fluorescence Microscopy Images

Giovanni De Micheli, Sandro Carrara, Julien Michel Ghaye, Danilo Demarchi, Paolo Silacci, Chiara Succa, Guy Vergères

State-of-the-art techniques for measuring and monitoring gene level expression rely on messenger RNA (mRNA) extraction and quantification, usually based on the concept of reverse transcription polymerase chain reaction. In this paper, we take adva ...

Ieee2014

Impact of milk processing on the generation of peptides during digestion

Martinus Gijs, Guy Vergères, Flurina Schwander, Reto Portmann

Milk processing may induce changes in dairy product composition and influence digestibility and nutrient bioavailability. Differences in protein degradation and peptide generation were studied for beta-lactoglobulin and alpha(S1)-casein from commercially a ...

Elsevier Sci Ltd2014

NutriChip: Nutrition Analysis meets Microfluidics

Martinus Gijs, Sandro Carrara, Paolo Silacci, Gözen Köklü, Julien Michel Ghaye, Hamideh Jafarpoorchekab, Christine Ruffert, Guy Vergères

This focus article introduces the concept of NutriChip, an integrated microfluidic platform for investigating the potential of the immuno-modulatory function of dairy food. The core component of the NutriChip is a miniaturized artificial human gastrointest ...

Royal Society of Chemistry2013

Image thresholding techniques for localization of sub-resolution fluorescent biomarkers

Giovanni De Micheli, Sandro Carrara, Paolo Silacci, Julien Michel Ghaye, Madhura Avinash Kamat, Guy Vergères

In this article, we explore adaptive global and local segmentation techniques for a lab-on-chip nutrition monitoring system (NutriChip). The experimental setup consists of Caco-2 intestinal cells that can be artificially stimulated to trigger an immune res ...

Wiley-Blackwell2013

The NutriChip project - translating technology into nutritional knowledge

Martinus Gijs, Sandro Carrara, Paolo Silacci, Guy Vergères, Flurina Schwander, Reto Portmann

Advances in food transformation have dramatically increased the diversity of products on the market and, consequently, exposed consumers to a complex spectrum of bioactive nutrients whose potential risks and benefits have mostly not been confidently demons ...

Cambridge University Press2012

NutriChip - A lab-on-a-chip platform to investigate food absorption and underlying immune regulations

Martinus Gijs, Paolo Silacci, Guy Vergères, Flurina Schwander, Reto Portmann

Federation Amer Soc Exp Biol2012

Gastrointestinal Tract on Chip

Martinus Gijs, Paolo Silacci, Hamideh Jafarpoorchekab, Guy Vergères

2012

Nutrichip: an integrated microfluidic system for in vitro investigation of the immunemodulatory function of dairy products

Martinus Gijs, Sandro Carrara, Paolo Silacci, Hamideh Jafarpoorchekab, Guy Vergères, Flurina Schwander

We introduce the concept of the NutriChip, a miniaturized artificial human gastrointestinal tract (GIT) for investigating the potential of immuno-modulatory function of dairy food. More specifically, we are investigating the effect of digested milk on immu ...

2011