Publications de Conlin O'Neil | EPFL Graph Search

Cytoplasmic Stopped Flow at the Single Cell Level Based on Photosensitive Polymersomes

Demetri Psaltis, Jeffrey Alan Hubbell, Andreas Vasdekis, Conlin O'Neil

Cell Press2014

Polymer micelles with pyridyl disulfide-coupled antigen travel through lymphatics and show enhanced cellular responses following immunization

Jeffrey Alan Hubbell, Melody Swartz, Sachiko Hirosue, Conlin O'Neil, Karen Dane, Jackson Eby

Poly(ethylene glycol)-stabilized poly(propylene sulfide) core (PEG-PPS) nanoparticles (NPs) smaller than 50 nm efficiently travel to draining lymph nodes and interact with antigen-presenting cells (APCs) to induce potent immune responses following intrader ...

Elsevier Sci Ltd2012

Precision Intracellular Delivery Based on Optofluidic Polymersome Rupture

Demetri Psaltis, Jeffrey Alan Hubbell, Andreas Vasdekis, Conlin O'Neil

We present an optical approach for intracellular delivery of molecules contained within oxidation-sensitive polymersomes. The photosensitizer ethyl eosin is associated with the polymersome membrane to oxidatively increase the hydrophilicity of the hydropho ...

American Chemical Society2012

Nano-sized drug-loaded micelles deliver payload to lymph node immune cells and prolong allograft survival

Jeffrey Alan Hubbell, Melody Swartz, Conlin O'Neil, Alice Anna Tomei, Karen Dane, Jackson Eby

By delivering immunomodulatory drugs in vivo directly to lymph nodes draining an injection site, an opportunity exists to increase drug bioavailability to local immune cells. Importantly, particles smaller than 100 nm are efficiently transported through ly ...

Elsevier2011

Analytical ultracentrifugation to support the development of biomaterials and biomedical devices

Jeffrey Alan Hubbell, Jutta Christine Wandrey, Conlin O'Neil, Urara Hasegawa

Analytical ultracentrifugation (AUC) primarily serves to investigate hydrodynamic and thermodynamic properties of natural and synthetic macromolecules and colloids in solution, dispersion or suspension. Beside such more conventional use, AUC can support ma ...

2011

Enzymatic- and temperature-sensitive controlled release of ultrasmall superparamagnetic iron oxides (USPIOs)

Jeffrey Alan Hubbell, Conlin O'Neil

Background: Drug and contrast agent delivery systems that achieve controlled release in the presence of enzymatic activity are becoming increasingly important, as enzymatic activity is a hallmark of a wide array of diseases, including cancer and atheroscle ...

2011

Enzymatic- and temperature-sensitive controlled release of ultrasmall superparamagnetic iron oxides (USPIOs) (vol 9, pg 7, 2011)

Jeffrey Alan Hubbell, Conlin O'Neil

2011

Synthesis of Pyridyl Disulfide-Functionalized Nanoparticles for Conjugating Thiol-Containing Small Molecules, Peptides, and Proteins

Jeffrey Alan Hubbell, Conlin O'Neil, Urara Hasegawa

Previously we reported emulsion polymerization of propylene sulfide with Pluronic F127 as an emulsifier, yielding nanoparticles (NPs) in the 25 nm size range. Immunologically functional NPs were prepared by adding an antigen Pluronic conjugate to the polym ...

2010

Block copolymers and uses thereof

Jeffrey Alan Hubbell, Melody Swartz, Conlin O'Neil

An encoding/decoding apparatus and method using a low-density parity-check code (LDPC code) is disclosed. Basic column group information, serving as a set of information regarding positions of rows with weight 1, is extracted from a reference column in eac ...

2010

Assessing the Role of Poly(ethylehe glycol-bl-propylene sulfide) (PEG-PPS) Block Copolymers in the Preparation of Carbon Nanotube Biocompatible Dispersions

Davide Demurtas, Jeffrey Alan Hubbell, Conlin O'Neil

Amphiphilic block copolymers based on hydrophobic polysulfides (poly(propylene sulfide), PPS) and hydrophilic polyethers (poly(ethylene glycol), PEG) have been used to solubilize and disperse single-walled carbon nanotubes (SWNTs). The obtained highly conc ...

American Chemical Society2010