Conlin O'Neil

Cette personne n’est plus à l’EPFL

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Publications associées (16)

Nanoparticles for immunotherapy

Jeffrey Alan Hubbell, Eleonora Simeoni, Melody Swartz, Conlin O'Neil, Sai Reddy

Nanoparticles that activate complement in the absence of biological molecules are described. The nanoparticles are shown to specifically target antigen presenting cells in specifically in lymph nodes, without the use of a biological molecule for targeting. ...

2010

A Novel Method for the Encapsulation of Biomolecules into Polymersomes via Direct Hydration

Jeffrey Alan Hubbell, Davide Demurtas, Conlin O'Neil, Andrija Finka

One of the major engineering challenges for the implementation of block copolymer vesicles, or polymersomes, as therapeutic drug carriers is obtaining high encapsulation efficiencies for biomolecules. Here we present it novel method for encapsulation of pr ...

2009

Aggregation Behavior of Poly(ethylene glycol-bl-propylene sulfide) Di- and Triblock Copolymers in Aqueous Solution

Jeffrey Alan Hubbell, Conlin O'Neil, Jacques Dubochet

Block copolymers of poly(ethylene glycol)-bl-poly(propylene sulfide) (PEG-PPS) have recently emerged as a new macromolecular amphiphile capable of forming a wide range of morphologies when dispersed in water. To understand better the relationship between s ...

2009

Novel applications of poly(ethylene glycol)-bl-poly(propylene sulfide) block copolymers

Conlin O'Neil

Block copolymers are comprised of repeating chemical groups (blocks) which commonly contain at least one hydrophilic block coupled to at least one hydrophobic block, forming an amphipathic macromolecule. This molecular arrangement drives the self assembly ...

EPFL2008

Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage

Jeffrey Alan Hubbell, Conlin O'Neil, Dominique André Rothenfluh

The extracellular matrix of dense, avascular tissues presents a barrier to entry for polymer-based therapeutics, such as drugs encapsulated within polymeric particles. Here, we present an approach by which polymer nanoparticles, suffciently small to enter ...

Nature Publishing Group2008

Superparamagnetic Nanoparticles as a Powerful Systems Biology. Characterization Tool in the Physiological Context

Heinrich Hofmann, Jeffrey Alan Hubbell, Alke Fink, Benedikt Steitz, Marc Moniatte, Conlin O'Neil, Andrija Finka, Jatuporn Salaklang

Recently, functionalized superparamagnetic iron oxide nanoparticles (SPIONs) have been utilized for protein separation and therapeutic delivery of DNA and drugs. The development of new methods and tools for the targeting and identification of specific biom ...

Wiley-Blackwell2008

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