Publications de Yun Suk Jo | EPFL Graph Search

Engineering integrin signaling for promoting embryonic stem cell self-renewal in a precisely defined niche

Jeffrey Alan Hubbell, Stephane Kontos, Seung Tae Lee, Yun Suk Jo, Jong Eun Ihm, Mayumi Mochizuki Martino, Jungim Yun

We present development and use of a 3D synthetic extracellular matrix (ECM) analog with integrin- specific adhesion ligands to characterize the microenvironmental influences in embryonic stem cell (ESC) self-renewal. Transcriptional analysis of 24 integrin ...

Elsevier2010

Micelles for delivery of nitric oxide

Jeffrey Alan Hubbell, Yun Suk Jo

Embodiments include a vehicle for delivery of nitric oxide comprising: a collection of micelles having an internal micelle core that comprises a polymer with N-diazeniumdiolate comprising NO complexed with secondary amines of the polymer. Embodiments inclu ...

2010

Tailoring hydrogel degradation and drug release via neighboring amino acid-controlled ester hydrolysis

Matthias Lütolf, Jeffrey Alan Hubbell, Yun Suk Jo, Jay Gantz

We present a versatile scheme to rationally modulate the hydrolysis rate of ester bonds in hydrophilic polymer networks via adjacent charged amino acids. As soluble model systems, two cysteine-bearing oligopeptides containing either positively charged argi ...

2009

Micelles for delivery of nitric oxide

Nikolaos Stergiopoulos, Davide Demurtas, Jeffrey Alan Hubbell, Simone Cavadini, Tyler Nerton Thacher, Yun Suk Jo, Jay Gantz

We designed block copolymer pro-amphiphiles and amphiphiles for providing very long-term release of nitric oxide (NO). A block copolymer of N-acryloylmorpholine (AM, as a hydrophile) and N-acryloyl-2,5-dimethylpiperazine (AZd, as a hydrophilic precursor) w ...

2009

Polymeric carriers for therapeutic agents : drug and gene delivery systems by reversible addition-fragmentation transfer (RAFT) polymerization

Yun Suk Jo

This thesis deals with development of polymeric carriers for many different therapeutic agents such as immune-suppressant drug (everolimus), nitric oxide (NO), and polynucleotide. Polymeric carriers developed in this project were all synthesized by reversi ...

EPFL2008

RAFT homo- and copolymerization of N-acryloyl-morpholine, piperidine, and azocane and their self-assembled structures

Jeffrey Alan Hubbell, Davide Demurtas, Yun Suk Jo, Jay Gantz

We present new polymeric amphiphiles derived from N-acryloyl derivatives of the cyclic secondary amines: morpholine, piperidine, and azocane polymerized by reversible addition -fragmentation transfer (RAFT) polymerization. Both homopolymerization and block ...

American Chemical Society2008

Bulk synthesis of transparent and homogeneous polymeric hybrid materials with ZnO quantum dots and PMMA

Yun Suk Jo

In situ sol-gel polymerization is demonstrated for fabricating transparent poly(methyl methacrylate) (PMMA)-ZnO quantum dot (QD)- hybrid materials in bulk dimension. The transparent PMMA-ZnO QD hybrid materials exhibit enhanced UV-shielding effects in the ...

Wiley2007