Personne
Jonathan Bieler
Cette personne n’est plus à l’EPFL
Publications associées (4)
Spatio-temporal synchronization of biological oscillators
The circadian clock is a cell-autonomous and self-sustained oscillator with a period of about 24 hours that controls many aspects of cellular physiology. The cell cycle is also a fundamental periodic process, with a period in the range of one day in mammal ...
EPFL2014Robust synchronization of coupled circadian and cell cycle oscillators in single mammalian cells
Felix Naef, Cédric Gobet, Kyle Gustafson, Jonathan Bieler, Rosamaria Cannavo
Circadian cycles and cell cycles are two fundamental periodic processes with a period in the range of 1 day. Consequently, coupling between such cycles can lead to synchronization. Here, we estimated the mutual interactions between the two oscillators by t ...
Nature / European Molecular Biology Organization2014Whole-embryo modeling of early segmentation in Drosophila identifies robust and fragile expression domains
Felix Naef, Christian Antonio Pozzorini, Jonathan Bieler
Segmentation of the Drosophila melanogaster embryo results from the dynamic establishment of spatial mRNA and protein patterns. Here, we exploit recent temporal mRNA and protein expression measurements on the full surface of the blastoderm to calibrate a d ...
2011Reconstructing the segmentation network in real space
The segmentation of the early Drosophila embryo has proven to be a fertile ground for experimentalists and modellers. Until now, most models have assumed a one-dimensional geometry along a portion of the anterior-posterior axis, motivated by the nearly rot ...
2009