Publications de Jean-Daniel Feuz

A Comprehensive Drosophila melanogaster Transcription Factor Interactome

Bart Deplancke, Riccardo Dainese, Jean-Daniel Feuz, Sachi Iiyama Inukai

Combinatorial interactions among transcription factors (TFs) play essential roles in generating gene expression specificity and diversity in metazoans. Using yeast 2-hybrid (Y2H) assays on nearly all sequence-specific Drosophila TFs, we identified 1,983 pr ...

2019

PDF Signaling Is an Integral Part of the Drosophila Circadian Molecular Oscillator

Bart Deplancke, Jean-Daniel Feuz

Circadian clocks generate 24-hr rhythms in physiology and behavior. Despite numerous studies, it is still uncertain how circadian rhythms emerge from their molecular and neural constituents. Here, we demonstrate a tight connection between the molecular and ...

Elsevier2016

A yeast one-hybrid and microfluidics-based pipeline to map mammalian gene regulatory networks

Bart Deplancke, Alina Isakova, Sebastian Martin Waszak, Jovan Simicevic, Sunil Kumar Raghav, Antonina Iagovitina, Carine Delattre-Gubelmann, Jean-Daniel Feuz

The comprehensive mapping of gene promoters and enhancers has significantly improved our understanding of how the mammalian regulatory genome is organized. An important challenge is to elucidate how these regulatory elements contribute to gene expression b ...

Nature / European Molecular Biology Organization2013

Automated protein-DNA interaction screening of Drosophila regulatory elements

Bart Deplancke, Andreas Massouras, Alina Isakova, Julien Bryois, Antonina Iagovitina, Jean-Daniel Feuz

Drosophila melanogaster has one of the best characterized metazoan genomes in terms of functionally annotated regulatory elements. To explore how these elements contribute to gene regulation, we need convenient tools to identify the proteins that bind to t ...

2011