Personne

Philippe Abdel Sayed

Publications associées (22)

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Intrinsic viscoelasticity increases temperature in knee cartilage under physiological loading

Dominique Pioletti, Philippe Abdel Sayed, Mohamadreza Nassajian Moghadam

Metabolism of proteoglycans and hyaluronic acid has been shown to be temperature- dependent in cartilage explants, with optimal anabolic effects between 36 1C and 38 1C. At rest, the temperature of human knee has a value of around 33 1C. We aim to show in ...

Elsevier2014

The role of energy dissipation of polymeric scaffolds in the mechanobiological modulation of chondrogenic expression

Dominique Pioletti, Philippe Abdel Sayed, Ulrike Kettenberger, Salim Elias Darwiche

Mechanical stimulation has been proposed to induce chondrogenesis in cell-seeded scaffold. However, the effects of mechanical stimuli on engineered cartilage may vary substantially between different scaffolds. This advocates for the need to identify an ove ...

2014

Mechanobiology is the analysis of the role of mechanical forces in educing a molecular response in cells. Nowadays, mechanobiology may contribute to clinical progress. In particular, mechanical stimulation has been proposed to induce chondrogenesis in engi ...

EPFL2013

Cartilage self-heating contributes to chondrogenic expression

Dominique Pioletti, Arne Christian Vogel, Philippe Abdel Sayed, Mohamadreza Nassajian Moghadam

Articular cartilage is a soft tissue showing inelastic properties. Under cyclic loading, inelastic materials may dissipate mechanical energy into heat. In knee cartilage, due to an intrinsic reduced heat convection related to its avascularity, a local temp ...

European Cells & Materials Ltd2013

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Knee cartilage is a soft tissue having viscoelastic properties. Under cyclic loadings, viscoelastic materials dissipate mechanical loadings through heat generation. In knee cartilage, this heat might not be convected because of the tissue avascularity, res ...

ASME2013

Intervertebral discs (IVD) are soft tissues that have viscoelastic behavior. Under cyclic loading, viscoelastic tissues dissipate the mechanical loading through the production of heat. In IVD, it is hypothesized that heat cannot be convected from the nucle ...

2012

Decellularized bovine IVD used as a scaffold for Tissue Engineering

Philippe Abdel Sayed

Currently several choices of scaffolds exist for tissue engineering purposes. Whereas a lot of works are done in the development of new material and hydrogels, very few efforts are spent for using decellularized ECM as scaffold for intervertebral disc repl ...

2011

Heat transfer in Interverterbral Discs (IVDs)

Philippe Abdel Sayed

The Nucleus Pulposus (NP) is an avascular tissue that may be subject to temperature increase. Indeed, since the NP is not perfused by the cardio-vascular system, it implies that heat cannot be convected from it. The sources of heat could be either external ...

2011

Decellularized tissues composed of extracellular matrix (ECM) and used as biologic scaffolds, have been shown to be useful for the repair of a variety of tissues. The clinical utility of such scaffolds for the tissue engineering of Nucleus Pulposus (NP) mi ...

2011

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Of the many external factors that affect cell behavior, mechanical cues have been found to be fundamental in modulating a cell’s phenotype. Indeed, merely changing substrate stiffness in monolayer culture systems generates drastically different phenotypes ...

2011