Sami Jannin

Cette personne n’est plus à l’EPFL

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Publications associées (61)

Highly Repeatable Dissolution Dynamic Nuclear Polarization for Heteronuclear NMR Metabolomics

Geoffrey Bodenhausen, Aurélien Bornet, Sami Jannin, Jonas Milani, Basile Vuichoud, Xiao Ji

At natural C-13 abundance, metabolomics based on heteronuclear NMR is limited by sensitivity. We have recently demonstrated how hyperpolarization by dissolution dynamic nuclear polarization (D-DNP) assisted by cross-polarization (CP) provides a reliable wa ...

Amer Chemical Soc2016

Structured and porous materials particularly suitable as polarizing agents in dissolution dynamic nuclear polarization

Geoffrey Bodenhausen, David Lyndon Emsley, Sami Jannin, Aurélien Bornet, David Benjamin Roger Antoine Gajan, David Baudouin

The present invention concerns materials consisting in a porous and structured network, this network being at least in part formed by Si atoms, or Si atoms and metal atoms, linked to each other by oxy bridges, comprising organic molecules which include at ...

2016

Filterable Agents for Hyperpolarization of Water, Metabolites, and Proteins

Geoffrey Bodenhausen, Aurélien Bornet, Pascal Miéville, Sami Jannin, Jonas Milani, Basile Vuichoud, Florian Patrick Marie Daniel De la Barre De Nanteuil, Estel Canet Martinez, Xiao Ji, Robert Konrat

Hyperpolarization is generated by dissolution dynamic nuclear polarization (d-DNP) using a polymer-based polarizing agent dubbed FLAP (filterable labeled agents for polarization). It consists of a thermo-responsive poly(N-isopropylacrylamide), also known a ...

Wiley-V C H Verlag Gmbh2016

Optimizing dissolution dynamic nuclear polarization

Aurélien Bornet, Sami Jannin

This article is a short review of some of our recent developments in dissolution dynamic nuclear polarization (d-DNP). We present the basic principles of d-DNP, and motivate our choice to step away from conventional approaches. We then introduce a modified ...

Academic Press Inc - Elsevier Science2016

Microwave-gated dynamic nuclear polarization

David Lyndon Emsley, Geoffrey Bodenhausen, Aurélien Bornet, Sami Jannin, Arthur César Pinon, Xiao Ji, Mathieu Baudin

Dissolution dynamic nuclear polarization (D-DNP) has become a method of choice to enhance signals in nuclear magnetic resonance (NMR). Recently, we have proposed to combine cross-polarization (CP) with D-DNP to provide high polarization P(C-13) in short bu ...

Royal Society of Chemistry2016

Homonuclear decoupling for spectral simplification of carbon-13 enriched molecules in solution-state NMR enhanced by dissolution DNP

Geoffrey Bodenhausen, Aurélien Bornet, Sami Jannin, Diego Carnevale, Srinivas Chinthalapalli

Complex overlapping multiplets due to scalar couplings (n)J(C-13, C-13) in fully C-13-enriched molecules can be simplified by polychromatic irradiation of selected spins. The signal intensities of the remaining non-irradiated signals are proportional to th ...

Royal Society of Chemistry2016

Hyperpolarized Water to Study Protein-Ligand Interactions

Geoffrey Bodenhausen, Aurélien Bornet, Sami Jannin, Jonas Milani, Basile Vuichoud, Quentin Chappuis

The affinity between a chosen target protein and small molecules is a key aspect of drug discovery. Screening by popular NMR methods such as Water-LOGSY suffers from low sensitivity and from false positives caused by aggregated or denatured proteins. This ...

2015

Spin Noise Detection of Nuclear Hyperpolarization at 1.2K

Geoffrey Bodenhausen, Aurélien Bornet, Sami Jannin, Jonas Milani, Basile Vuichoud

We report proton spin noise spectra of a hyperpolarized solid sample of commonly used DNP (dynamic nuclear polarization) juice containing TEMPOL (4-hydroxy-2,2,6,6-tetramethylpiperidine N-oxide) and irradiated by a microwave field at a temperature of 1.2K ...

Wiley-Blackwell2015

A magnetic tunnel to shelter hyperpolarized fluids

Geoffrey Bodenhausen, Aurélien Bornet, Pascal Miéville, Sami Jannin, Jonas Milani, Basile Vuichoud, Roger Mottier

To shield solutions carrying hyperpolarized nuclear magnetization from rapid relaxation during transfer through low fields, the transfer duct can be threaded through an array of permanent magnets. The advantages are illustrated for solutions containing hyp ...

American Institute of Physics2015

Hyperpolarized para-Ethanol

Geoffrey Bodenhausen, Aurélien Bornet, Sami Jannin, Jonas Milani, Basile Vuichoud, Daniele Mammoli

We show that an imbalance between the populations of singlet (S) and triplet (T) states in pairs of magnetically equivalent spins can be generated by dissolution dynamic nudear polarization: In partly deuterated ethanol ((CD3CH2OD)-C-13), this T/S imbalanc ...

Amer Chemical Soc2015

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Homonuclear decoupling for spectral simplification of carbon-13 enriched molecules in solution-state NMR enhanced by dissolution DNP

Geoffrey Bodenhausen, Aurélien Bornet, Sami Jannin, Diego Carnevale, Srinivas Chinthalapalli

Royal Society of Chemistry2016