Publications de Rafaela Fernandes Da Silva

Apelin-13 Protects Corpus Cavernosum Against Fibrosis Induced by High-Fat Diet in an MMP-Dependent Mechanism

Nikolaos Stergiopoulos, Mikaël Nils Sturny, Rafaela Fernandes Da Silva, Augusto Martins Lima, Fabiana Pereira Da Costa Fraga, Maiia Bragina, Léa Liliane Colette Anguenot

Background: An increased fibrosis of the corpora cavernosa is a prevalent process that underlies most cases of erectile dysfunction. Apelin, an endogenous circulating peptide, has been documented as an important effector on cardiovascular homeostasis, cont ...

ELSEVIER SCI LTD2021

Age-related changes in vascular responses to angiotensin-(1-7) in female mice

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Fabiana Pereira Da Costa Fraga, Luciano Dos Santos Aggum Capettini

2018

Apelin-13 treatment enhances the stability of atherosclerotic plaques

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Fabiana Pereira Da Costa Fraga, Léa Liliane Colette Anguenot

2018

PROTECTIVE EFFECT OF APELIN-13 AGAINST HYPERCHOLESTEROLEMIA-INDUCED FIBROSIS OF THE CORPUS CAVERNOSUM

Nikolaos Stergiopoulos, Mikaël Nils Sturny, Rafaela Fernandes Da Silva, Fabiana Pereira Da Costa Fraga, Augusto Martins Lima, Maiia Bragina, Léa Liliane Colette Anguenot

2018

Apelin-13 treatment enhances the stability of atherosclerotic plaques

Nikolaos Stergiopoulos, Rodrigo Araujo Fraga Da Silva, Rafaela Fernandes Da Silva, Fabiana Pereira Da Costa Fraga, Léa Liliane Colette Anguenot

Oxford Univ Press2016

Apelin-13 Protects Corpus Cavernosum Against Fibrosis Induced By Hypercholesterolemia

Nikolaos Stergiopoulos, Mikaël Nils Sturny, Rafaela Fernandes Da Silva, Fabiana Pereira Da Costa Fraga, Léa Liliane Colette Anguenot

Wiley-Blackwell2016

Diminazene Protects Corpus Cavernosum Against Hypercholesterolemia-Induced Injury

Nikolaos Stergiopoulos, Mikaël Nils Sturny, Rafaela Fernandes Da Silva, Fabiana Pereira Da Costa Fraga, Younouss Faye

IntroductionAngiotensin-converting enzyme 2 (ACE2) is a key enzyme of the renin angiotensin system, which breaks down angiotensin II and forms angiotensin-(1-7). In erectile tissues, it has been documented that angiotensin II contributes to the development ...

Wiley-Blackwell2015

Diminazene enhances stability of atherosclerotic plaques in ApoE-deficient mice

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Maiia Bragina, Fabiana Pereira Da Costa Fraga

Angiotensin (Ang) II contributes to the development of atherosclerosis, while Ang-(1-7) has atheroprotective actions. Accordingly, angiotensin-converting enzyme 2 (ACE2), which breaks-down Aug 11 and forms Ang-(1-7), has been suggested as a target against ...

Elsevier2015

Nicotinamide phosphoribosyltransferase inhibition reduces intraplaque CXCL1 production and associated neutrophil infiltration in atherosclerotic mice

Nikolaos Stergiopoulos, Katia Galan, Rafaela Fernandes Da Silva

Pharmacological treatments targeting CXC chemokines and the associated neutrophil activation and recruitment into atherosclerotic plaques hold promise for treating cardiovascular disorders. Therefore, we investigated whether FK866, a nicotinamide phosphori ...

Schattauer2014

Treatment with Angiotensin-(1-7) reduces inflammation in carotid atherosclerotic plaques

Nikolaos Stergiopoulos, Katia Galan, Rafaela Fernandes Da Silva, Fabiana Pereira Da Costa Fraga, Luciano Dos Santos Aggum Capettini

Angiotensin (Ang)-(1-7), acting through the receptor Mas, has athero-protective effects; however, its role on plaque vulnerability has been poorly studied. Here, we investigated the expression of the renin-angiotensin system (RAS) components in stable and ...

Schattauer2014