Publications de Igor Allaman | EPFL Graph Search

Lactate in the brain: from metabolic end-product to signalling molecule

Lactate in the brain has long been associated with ischaemia; however, more recent evidence shows that it can be found there under physiological conditions. In the brain, lactate is formed predominantly in astrocytes from glucose or glycogen in response to ...

2018

Dual action of L-Lactate on the activity of NR2B-containing NMDA receptors: from potentiation to neuroprotection

Pierre Magistretti, Igor Allaman, Pierre Marquet, Pascal Jourdain, Kaspar Rothenfusser

L-Lactate is a positive modulator of NMDAR-mediated signaling resulting in plasticity gene induction and memory consolidation. However, L-Lactate is also able to protect neurons against excito-toxic NMDAR activity, an indication of a mitigating action of L ...

Nature Research2018

Functional consequences of brain glycogen deficiency on the sleep-wake cycle regulation in PTG-KO mice

Pierre Magistretti, Igor Allaman, Gabriele Grenningloh, Sophie Burlet Godinot

WILEY2018

Synergistic interaction of L-Lactate and Glycine to potentiate NMDA receptor activity: a new form of meta-potentiation?

Pierre Magistretti, Igor Allaman, Pierre Marquet, Pascal Jourdain, Kaspar Rothenfusser

Wiley2017

Lack of PTG involvement in glycogen regulation during sleep deprivation in mice

Pierre Magistretti, Igor Allaman, Gabriele Grenningloh, Evelyne Ruchti, Jean-Marie Petit, Sophie Burlet Godinot, Jin Teng Chung

Wiley2017

L-Lactate protects neurons against excitotoxicity: implication of an ATP-mediated signaling cascade

Pierre Magistretti, Igor Allaman, Pierre Marquet, Pascal Jourdain, Kaspar Rothenfusser

Converging experimental data indicate a neuroprotective action of L-Lactate. Using Digital Holographic Microscopy, we observe that transient application of glutamate (100 μM; 2 min) elicits a NMDA-dependent death in 65% of mouse cortical neurons in culture ...

Nature Research2016

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

Pierre Magistretti, Igor Allaman

The energy demands of the brain are high: they account for at least 20% of the body's energy consumption. Evolutionary studies indicate that the emergence of higher cognitive functions in humans is associated with an increased glucose utilization and expre ...

Elsevier2015

Role of glycogen-derived lactate in synaptic plasticity and memory

Pierre Magistretti, Igor Allaman, Gabriele Grenningloh

Wiley-Blackwell2015

Modulation of astrocytic glucose metabolism by the antidiabetic drug metformin

Pierre Magistretti, Gabriele Grenningloh, Igor Allaman

Wiley-Blackwell2015

Methylglyoxal, the dark side of glycolysis

Pierre Magistretti, Igor Allaman

Glucose is the main energy substrate for the brain. There is now extensive evidence indicating that the metabolic profile of neural cells with regard to glucose utilization and glycolysis rate is not homogenous, with a marked propensity for glycolytic gluc ...

Frontiers Research Foundation2015