Pierre Gönczy

Publications associées (110)

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Centriole Biogenesis: From Identifying the Characters to Understanding the Plot

Pierre Gönczy, Niccolo Banterle

The centriole is a beautiful microtubule-based organelle that is critical for the proper execution of many fundamental cellular processes, including polarity, motility, and division. Centriole biogenesis, the making of this miniature architectural wonder, ...

Annual Reviews2017

Cell-free reconstitution reveals centriole cartwheel assembly mechanisms

Henning Paul-Julius Stahlberg, Pierre Gönczy, Niccolo Banterle, Paul Guichard, Mircea Ioan Iacovache, Virginie Hamel, Isabelle Fluckiger, Veronika Nemcíková Villímová

How cellular organelles assemble is a fundamental question in biology. The centriole organelle organizes around a nine-foldsymmetrical cartwheel structure typically 100 nm high comprising a stack of rings that each accommodates nine homodimers of SAS-6 pro ...

Springer Nature2017

Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis

Pierre Gönczy, Romain Hamelin, Florence Armand, Coralie Busso, Paul Guichard, Virginie Hamel, Isabelle Fluckiger

Centrioles are evolutionarily conserved macromolecular structures that are fundamental to form cilia, flagella, and centrosomes. Centrioles are 9-fold symmetrical microtubule-based cylindrical barrels comprising three regions that can be clearly distinguis ...

2017

An Integrated Microfluidic Device For C-Elegans Early Embryogenesis Studies And Drug Assays

Martinus Gijs, Pierre Gönczy, Thomas Lehnert, Matteo Cornaglia, Li Dong, Radek Jankele, Jingwei Zhang

The Caenorhabditis elegans embryo is a widely used model for the functional analysis of dynamic cellular processes, such as chromosome segregation, cytokinesis or lineage analysis. However, the conventional embryo preparation method that relies on manually ...

Ieee2017

Chemical Genetic Screen Identifies Natural Products that Modulate Centriole Number

Kai Johnsson, Pierre Gönczy, Michele Graciotti, Zhou Fang

Centrioles are microtubule-based organelles found in most eukaryotic cells and that are critical for the formation of cilia and flagella, as well as of centrosomes in animal cells. The number of centrioles must be strictly regulated in proliferating cells ...

Wiley-Blackwell2016

Distinct mechanisms eliminate mother and daughter centrioles in meiosis of starfish oocytes

Pierre Gönczy

Centriole elimination is an essential process that occurs in female meiosis of metazoa to reset centriole number in the zygote at fertilization. How centrioles are eliminated remains poorly understood. Here we visualize the entire elimination process live ...

Rockefeller University Press2016

The Human Centriolar Protein CEP135 Contains a Two-Stranded Coiled-Coil Domain Critical for Microtubule Binding

Pierre Gönczy, Paul Guichard, Georgios Hatzopoulos

Centrioles are microtubule-based structures that play important roles notably in cell division and cilium biogenesis. CEP135/Bld10p family members are evolutionarily conserved microtubule-binding proteins important for centriole formation. Here, we analyze ...

Elsevier2016

SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture

Pierre Gönczy, Virginie Hamel, Paul Guichard

Centrioles are critical for the formation of centrosomes, cilia and flagella in eukaryotes. They are thought to assemble around a nine-fold symmetric cartwheel structure established by SAS-6 proteins. Here, we have engineered Chlamydomonas reinhardtii SAS- ...

Nature Publishing Group2016

Dynein Transmits Polarized Actomyosin Cortical Flows to Promote Centrosome Separation

Pierre Gönczy, Alessandro De Simone

The two centrosomes present at the onset of mitosis must separate in a timely and accurate fashion to ensure proper bipolar spindle assembly. The minus-end-directed motor dynein plays a pivotal role in centrosome separation, but the underlying mechanisms r ...

Elsevier2016

Aurora A kinase regulates proper spindle positioning in C-elegans and in human cells

Pierre Gönczy, Coralie Busso, Sachin Kotak

Accurate spindle positioning is essential for error-free cell division. The one-cell Caenorhabditis elegans embryo has proven instrumental for dissecting mechanisms governing spindle positioning. Despite important progress, how the cortical forces that act ...

2016

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