Publications de Dominique André Rothenfluh

Peptide ligands for targeting and retention of nanoparticles and protein therapeutics in articular cartilage

Osteoarthritis (OA) is one of the most common causes of pain and disability. Currently, non-surgical treatment is limited to analgesic and anti-inflammatory drugs, which are not capable of either modifying the disease process or regenerate damaged parts in ...

EPFL2009

Integration column: Biofunctional polymeric nanoparticles for spatio-temporal control of drug delivery and biomedical applications

Jeffrey Alan Hubbell, Dominique André Rothenfluh

Polymeric nanoparticle technology has evolved from drug carrier design to advanced multifunctional macromolecular structures. They enable drug delivery and release of a bioactive under spatio-temporal control rather than just passive release by a long-circ ...

2009

Recombinant FGF-18 with a collagen II binding domain prevents cartilage degeneration in mice over five weeks after two intra-articular injections

Jeffrey Alan Hubbell, Mikaël Martino, Dominique André Rothenfluh

2009

Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability

Jeffrey Alan Hubbell, Mikaël Martino, Dominique André Rothenfluh, Thomas Barker, Mayumi Mochizuki Martino

The extracellular matrix (ECM) exerts powerful control over many cellular phenomena, including stem cell differentiation. As such, design and modulation of ECM analogs to ligate specific integrin is a promising approach to control cellular processes in vit ...

Elsevier2008

Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage

Jeffrey Alan Hubbell, Conlin O'Neil, Dominique André Rothenfluh

The extracellular matrix of dense, avascular tissues presents a barrier to entry for polymer-based therapeutics, such as drugs encapsulated within polymeric particles. Here, we present an approach by which polymer nanoparticles, suffciently small to enter ...

Nature Publishing Group2008

Polypeptide ligands for targeting cartilage and methods of use thereof

Jeffrey Alan Hubbell, Dominique André Rothenfluh

Ligands that specifically bind to articular cartilage tissues are disclosed, including uses for targeting therapeutics towards articular cartilage tissue and new materials for articular cartilage. The ligands are effective in vivo to target therapeutic mat ...

2008