Personne
Dominique André Rothenfluh
Cette personne n’est plus à l’EPFL
Publications associées (6)
Peptide ligands for targeting and retention of nanoparticles and protein therapeutics in articular cartilage
Osteoarthritis (OA) is one of the most common causes of pain and disability. Currently, non-surgical treatment is limited to analgesic and anti-inflammatory drugs, which are not capable of either modifying the disease process or regenerate damaged parts in ...
EPFL2009Integration column: Biofunctional polymeric nanoparticles for spatio-temporal control of drug delivery and biomedical applications
Jeffrey Alan Hubbell, Dominique André Rothenfluh
Polymeric nanoparticle technology has evolved from drug carrier design to advanced multifunctional macromolecular structures. They enable drug delivery and release of a bioactive under spatio-temporal control rather than just passive release by a long-circ ...
2009Block copolymers for siRNA delivery
Dominique André Rothenfluh, Marc Keller
The discovery of the RNA interference (RNAi) pathway in plants in the early 90's and the subsequent demonstration of its presence in mammalian cells in 2001 were a major breakthrough in biological research. Indeed it was quickly realized that this highly s ...
2008Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability
Jeffrey Alan Hubbell, Mikaël Martino, Dominique André Rothenfluh, Thomas Barker, Mayumi Mochizuki Martino
The extracellular matrix (ECM) exerts powerful control over many cellular phenomena, including stem cell differentiation. As such, design and modulation of ECM analogs to ligate specific integrin is a promising approach to control cellular processes in vit ...
Elsevier2008Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage
Jeffrey Alan Hubbell, Conlin O'Neil, Dominique André Rothenfluh
The extracellular matrix of dense, avascular tissues presents a barrier to entry for polymer-based therapeutics, such as drugs encapsulated within polymeric particles. Here, we present an approach by which polymer nanoparticles, suffciently small to enter ...
Nature Publishing Group2008Polypeptide ligands for targeting cartilage and methods of use thereof
Jeffrey Alan Hubbell, Dominique André Rothenfluh
Ligands that specifically bind to articular cartilage tissues are disclosed, including uses for targeting therapeutics towards articular cartilage tissue and new materials for articular cartilage. The ligands are effective in vivo to target therapeutic mat ...
2008