Publications de Hélène Danielle Perreten Lambert

Distinct fission signatures predict mitochondrial degradation or biogenesis

Suliana Manley, Hélène Danielle Perreten Lambert, Julius Hans Bernd Winter, Dora Mahecic, Timo Henry René Rey, Tatjana Isabelle Kleele

Mitochondrial fission is a highly regulated process that, when disrupted, can alter metabolism, proliferation and apoptosis(1-3). Dysregulation has been linked to neurodegeneration(3,4), cardiovascular disease(3) and cancer(5). Key components of the fissio ...

2021

Control of Mitochondrial pH by Uncoupling Protein 4 in Astrocytes Promotes Neuronal Survival

Pierre Magistretti, Hélène Danielle Perreten Lambert, Sylvain Eric Lengacher, Manuel Raphael Zenger, Jean-Yves Chatton

Brain activity is energetically costly and requires a steady and highly regulated flow of energy equivalents between neural cells. It is believed that a substantial share of cerebral glucose, the major source of energy of the brain, will preferentially be ...

American Society for Biochemistry and Molecular Biology2014

Glutamate transport decreases mitochondrial pH and modulates oxidative metabolism in astrocytes

Hélène Danielle Perreten Lambert, Sylvain Eric Lengacher, Jean-Yves Chatton

During synaptic activity, the clearance of neuronally released glutamate leads to an intracellular sodium concentration increase in astrocytes that is associated with significant metabolic cost. The proximity of mitochondria at glutamate uptake sites in as ...

2011

Lentiviral Transgenesis as a Tool to Study the Role of Uncoupling Protein Isoforms in the Nervous System

Hélène Danielle Perreten Lambert

A tight coupling exists between synaptic activity and glucose utilization by astrocytes. Metabolic cooperation between neurons and astrocytes mediates this coupling. During synaptic activation, glutamate that is released in the synaptic cleft as a neurotra ...

EPFL2011