Publications de Lijing Xin | EPFL Graph Search

Rosette Spectroscopic Imaging for Whole-Brain Slab Metabolite Mapping at 7T: Acceleration Potential and Reproducibility

Lijing Xin, Mark Stephan Widmaier, André Döring

Whole-brain proton magnetic resonance spectroscopic imaging (H-1-MRSI) is a non-invasive technique for assessing neurochemical distribution in the brain, offering valuable insights into brain functions and neural diseases. It greatly benefits from the impr ...

Wiley2025

Fast 3D 31P B1+ mapping with a weighted stack of spiral trajectory at 7 T

Lijing Xin, Katarzyna Pierzchala, Daniel Wenz, Mark Stephan Widmaier

Purpose: Phosphorus MRS (31P MRS) enables noninvasive assessment of energy metabolism, yet its application is hindered by sensitivity limitations. To overcome this, often high magnetic fields are used, leading to challenges such as spatial (Formula present ...

Wiley2025

Neurochemical characteristics of pathological tissues in epilepsy: A preliminary 1H MR spectroscopy study at 7 T

Lijing Xin

Background and purpose: This study aims to evaluate the neurochemical characteristics of pathological tissues by 1H magnetic resonance spectroscopy (MRS) in patient with pharmaco-resistant focal epilepsy at 7 T. Methods: Thirteen patients with drug-resista ...

2025

A graphical pipeline platform for MRS data processing and analysis: MRSpecLAB

Lijing Xin, Mark Stephan Widmaier, André Döring

Magnetic resonance spectroscopy (MRS) and magnetic resonance spectroscopic imaging (MRSI), are non-invasive techniques used to quantify biochemical compounds in tissue, such as choline, creatine, glutamate, glutamine, γ-aminobutyric acid, N-acetylaspartate ...

2025

CEST imaging combined with 1H-MRS reveal the neuroprotective effects of riluzole by improving neurotransmitter imbalances in Alzheimer's disease mice

Lijing Xin

BackgroundThe imbalance of glutamate (Glu) and gamma-aminobutyric acid (GABA) neurotransmitter system plays a crucial role in the pathogenesis of Alzheimer's disease (AD). Riluzole is a Glu modulator originally approved for amyotrophic lateral sclerosis th ...

BMC2025

NMR-based metabolomics combined with metabolic pathway analysis reveals metabolic heterogeneity of colorectal cancer tissue at different anatomical locations and stages

Lijing Xin

Colorectal cancer (CRC) still remains the leading cause of cancer death worldwide. This study aimed to profile the metabolic differences of colorectal cancer tissues (CCT) at different stages and sites, as compared with their distant noncancerous tissues ( ...

2024

Twisted pair transmission line coil - a flexible, self-decoupled and robust element for 7 T MRI

Lijing Xin, Daniel Wenz

Objective: This study evaluates the performance of a twisted pair transmission line coil as a transceive element for 7 T MRI in terms of physical flexibility, robustness to shape deformations, and interelement decoupling. Methods: Each coil element was cre ...

Elsevier Science Inc2024

Five percent CO2 inhalation alleviates hippocampal glutamate and water homeostasis disturbance, neuronal damage, and learning-memory impairment in sleep-deprived rats

Lijing Xin

Background: Sleep deprivation causes hippocampal injury, manifesting as neuronal damage and learning-memory impairment. These negative effects may be associated with disturbance of hippocampal glutamate and water homeostasis, which induces excessive neuron ...

2024

Editorial for “Human Brain Deuterium Metabolic Imaging at 7 T: Impact of Different [6,6'-2H2]Glucose Doses”

Lijing Xin

2024

A neurometabolic mechanism involving dmPFC/dACC lactate in physical effort-based decision-making

Maria del Carmen Sandi Perez, Lijing Xin, Nicolas Clairis, Arthur Barakat

Motivation levels vary across individuals, yet the underlying mechanisms driving these differences remain elusive. The dorsomedial prefrontal cortex/dorsal anterior cingulate cortex (dmPFC/dACC) and the anterior insula (aIns) play crucial roles in effort-b ...

Springer Science and Business Media LLC2024