Ralf Schneggenburger

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Publications associées (38)

Integration of excitation and inhibition in a binaural auditory nucleus

Ralf Schneggenburger

Wiley-Blackwell2014

An Alien Divalent Ion Reveals a Major Role for Ca2+ Buffering in Controlling Slow Transmitter Release

Ralf Schneggenburger, Olexiy Kochubey, Daniel Keller, Zsolt Norbert Babai

Ca2+-dependent transmitter release occurs in a fast and in a slow phase, but the differential roles of Ca2+ buffers and Ca2+ sensors in shaping release kinetics are still controversial. Replacing extracellular Ca2+ by Sr2+ causes decreased fast release but ...

2014

Munc18-1 is a dynamically regulated PKC target during short-term enhancement of transmitter release

Ralf Schneggenburger, Olexiy Kochubey, Özgür Genç

Transmitter release at synapses is regulated by preceding neuronal activity, which can give rise to short-term enhancement of release like post-tetanic potentiation (PTP). Diacylglycerol (DAG) and Protein-kinase C (PKC) signaling in the nerve terminal have ...

Elife Sciences Publications Ltd2014

Molecular identity of Ca2+ sensors for transmitter release at the developing calyx of Held

Ralf Schneggenburger, Olexiy Kochubey

Wiley-Blackwell2014

Molecular mechanisms that specify fast-transmitting synapses in the auditory system

Ralf Schneggenburger

Wiley-Blackwell2014

Robo3-Driven Axon Midline Crossing Conditions Functional Maturation of a Large Commissural Synapse

Ralf Schneggenburger, Zsolt Norbert Babai

During the formation of neuronal circuits, axon pathfinding decisions specify the location of synapses on the correct brain side and in correct target areas. We investigated a possible link between axon midline crossing and the subsequent development of ou ...

Elsevier2013

BMP signaling specifies the development of a large and fast CNS synapse

Graham Knott, Ralf Schneggenburger, Enida Gjoni, Le Xiao, Elin Kristina Kronander

excitatory synapses with multiple active zones ensure reliable and fast information transfer at specific points in neuronal circuits. However, the mechanisms that determine synapse size in CNS circuits are largely unknown. Here we use the calyx of Held syn ...

Nature Publishing Group2013

Ca2+ channels and transmitter release at the active zone

Ralf Schneggenburger, Olexiy Kochubey, Yunyun Han

Ca2+-dependent transmitter release is the most important signaling mechanism for fast information transfer between neurons. Transmitter release takes places at highly specialized active zones with sub-micrometer dimension, which contain the molecular machi ...

Elsevier2012

Nigrostriatal overabundance of alpha-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity

Patrick Aebischer, Graham Knott, Marco Cantoni, Ralf Schneggenburger, Özgür Genç, Jean-Charles Bensadoun, Wojciech Janusz Bobela, Safa Mohanna

alpha-Synuclein (alpha-syn) is a presynaptic protein present at most nerve terminals, but its function remains largely unknown. The familial forms of Parkinson's disease associated with multiplications of the alpha-syn gene locus indicate that overabundanc ...

Springer-Verlag2012

Regulation of transmitter release by Ca2+ and synaptotagmin: insights from a large CNS synapse

Ralf Schneggenburger, Olexiy Kochubey

Transmitter release at synapses is driven by elevated intracellular Ca2+ concentration (Ca2+) near the sites of vesicle fusion. Ca2+ signals of profoundly different amplitude and kinetics drive the phasic release component during a presynaptic ac ...

2011

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Nigrostriatal overabundance of alpha-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity

Patrick Aebischer, Graham Knott, Marco Cantoni, Ralf Schneggenburger, Özgür Genç, Jean-Charles Bensadoun, Wojciech Janusz Bobela, Safa Mohanna

Springer-Verlag2012

Molecular mechanisms that specify fast-transmitting synapses in the auditory system

Ralf Schneggenburger

Wiley-Blackwell2014