Publications de Lisa Conboy | EPFL Graph Search

Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety, depression, and memory-related behaviors

Maria del Carmen Sandi Perez, Hilal Lashuel, Jorge Eduardo Castro Cifuentes, Lisa Conboy

Intensive research is devoted to unravel the neurobiological mechanisms mediating adult hippocampal neurogenesis, its regulation by antidepressants, and its behavioral consequences. Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokin ...

Nature Publishing Group2011

Stress at learning facilitates memory formation by regulating AMPA receptor trafficking through a glucocorticoid action

Maria del Carmen Sandi Perez, Lisa Conboy

Stress and glucocorticoids (GCs) can facilitate memory formation. However, the molecular mechanisms mediating their effects are largely unknown. alpha-Amino-3-hydroxy-5- methyl-4-isoxazolepropionic acid (AMPA) receptor (AMPAR) trafficking has been implicat ...

Nature Publishing Group2010

Role of NCAM in emotion and learning

Maria del Carmen Sandi Perez, Kamila Markram, Reto Bisaz, Lisa Conboy

NCAM is an abundant cell adhesion molecule known to be important during development. Together with its posttranslational modification consisting of the addition of the polysaccharide polysialic acid (PSA), NCAM has been classically implicated in the regula ...

2010

The antidepressant agomelatine blocks the adverse effects of stress on memory and enables spatial learning to rapidly increase neural cell adhesion molecule (NCAM) expression in the hippocampus of rats

Maria del Carmen Sandi Perez, Lisa Conboy

Agomelatine, a novel antidepressant with established clinical efficacy, acts as a melatonin receptor agonist and 5-HT(2C) receptor antagonist. As stress is a significant risk factor in the development of depression, we sought to determine if chronic agomel ...

Cambridge University Press2009

Learning under stress: a role for the neural cell adhesion molecule NCAM

Maria del Carmen Sandi Perez, Reto Bisaz, Lisa Conboy

Stress is known to be a potent modulator of brain function and cognition. While prolonged and/or excessive stress generally exerts negative effects on learning and memory processes, acute stress can have differential effects on memory function depending on ...

Elsevier2009

Fear conditioning enhances spontaneous AMPA receptor-mediated synaptic transmission in mouse hippocampal CA1 area

Maria del Carmen Sandi Perez, Lisa Conboy

AMPA receptor-mediated synaptic modifications in the amygdala have been reported to sustain cued fear conditioning. However, the hippocampal formation is also critically involved in fear learning. Therefore, we examined whether fear conditioning is also ac ...

Wiley-Blackwell2009