Publications de Ulrike Haessler

Migration dynamics of breast cancer cells in a tunable 3D interstitial flow chamber

Philippe Renaud, Melody Swartz, Ulrike Haessler, Jeremy Teo

The migration of cells such as leukocytes, tumor cells, and fibroblasts through 3D matrices is critical for regulating homeostasis and immunity and for driving pathogenesis. Interstitial flow through the extracellular matrix, which can substantially increa ...

2012

Dendritic cell chemotaxis in 3D under defined chemokine gradients reveals differential response to ligands CCL21 and CCL19

Melody Swartz, Marco Pisano, Ulrike Haessler, Mingming Wu

Dendritic cell (DC) homing to the lymphatics and positioning within the lymph node is important for adaptive immunity, and is regulated by gradients of CCL19 and CCL21, ligands for CCR7. Despite the importance of DC chemotaxis, it is not well understood ho ...

National Academy of Sciences2011

Dendritic cell chemotaxis in 3D : new tools and insights

Ulrike Haessler

Dendritic cells (DCs) are crucial for the onset of adaptive immunity. Their outstanding migratory capacities in combination with their antigen presenting properties make them perfectly suited to pick up antigens in the periphery and transport them to the l ...

EPFL2010

An agarose-based microfluidic platform with a gradient buffer for 3D chemotaxis studies

Melody Swartz, Ulrike Haessler, Mingming Wu

The current state-of-art in 3D microfluidic chemotaxis device (mu FCD) is limited by the inherent coupling of the fluid flow and chemical concentration gradients. Here, we present an agarose-based 3D mu FCD that decouples these two important parameters, in ...

Springer Verlag2009