Publications de Freddy Radtke | EPFL Graph Search

Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs

Innate-like splenic marginal zone (MZ) B (MZB) cells play unique roles in immunity due to their rapid responsiveness to blood-borne microbes. How MZB cells integrate cell-extrinsic and -intrinsic processes to achieve accelerated responsiveness is unclear. ...

2025

Early Notch signals from fibroblastic reticular cells program effector CD8+ T cell differentiation

Freddy Radtke, Ute Koch

A better understanding of the mechanisms regulating CD8+ T cell differentiation is essential to develop new strategies to fight infections and cancer. Using genetic mouse models and blocking antibodies, we uncovered cellular and molecular mechanisms by whi ...

ROCKEFELLER UNIV PRESS2025

Reciprocal inhibition of NOTCH and SOX2 shapes tumor cell plasticity and therapeutic escape in triple-negative breast cancer

Freddy Radtke, Nadine Fournier

Cancer cell plasticity contributes significantly to the failure of chemo- and targeted therapies in triple-negative breast cancer (TNBC). Molecular mechanisms of therapy-induced tumor cell plasticity and associated resistance are largely unknown. Using a g ...

2024

Bcl-xL targeting eliminates ageing tumor-promoting neutrophils and inhibits lung tumor growth

Freddy Radtke, Nadine Fournier, Amber Dawn Bowler, Etienne Meylan, Anita Bodac, Justine Pascual, Vincent Roh

Elevated peripheral blood and tumor-infiltrating neutrophils are often associated with a poor patient prognosis. However, therapeutic strategies to target these cells are difficult to implement due to the life-threatening risk of neutropenia. In a genetica ...

Springernature2024

Spatiotemporally resolved colorectal oncogenesis in mini-colons ex vivo

Freddy Radtke, Matthias Lütolf, Nicolas Antoine Vincent Broguiere, Tania Hübscher, Luis Francisco Lorenzo Martin, Amber Dawn Bowler

Three-dimensional organoid culture technologies have revolutionized cancer research by allowing for more realistic and scalable reproductions of both tumour and microenvironmental structures 1-3 . This has enabled better modelling of low-complexity cancer ...

NATURE PORTFOLIO2024

Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis

Freddy Radtke, Ute Koch, Jialin Zhang, Soufiane Boumahdi

Self-renewal and differentiation of stem and progenitor cells are tightly regulated to ensure tissue homeostasis. This regulation is enabled both remotely by systemic circulating cues, such as cytokines and hormones, and locally by various niche-confined f ...

ELSEVIER2023

Notch1 signaling is limited in healthy mature kidneys in vivo

Freddy Radtke

ObjectiveA Delta-Notch signaling component, Notch1, is involved in the normal development and multiple disorders of the kidney. Although the increase in Notch1 signaling is crucial to these pathogeneses, the basal signaling level in 'healthy' mature kidney ...

SPRINGERNATURE2023

Resistance mechanism to Notch inhibition and combination therapy in human T-cell acute lymphoblastic leukemia

Freddy Radtke, Romain Hamelin, Nadine Fournier, Florence Armand, Maria Pavlou, Linlin Cao

Gain-of-function mutations in NOTCH1 are among the most frequent genetic alterations in T-cell acute lymphoblastic leukemia (T-ALL), highlighting the Notch signaling pathway as a promising therapeutic target for personalized medicine. Yet, a major limitati ...

2023

Stroma-Driven Notch2 Signaling Controls Naive B Cell Fate By Regulating Microenvironmental Positioning within the Spleen

Freddy Radtke, Ute Koch

Amer Soc Hematology2023

Unraveling proteoglycofili: a potential new neutrophil defense mechanism

Freddy Radtke, Amber Dawn Bowler

Hoboken2023