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Ana Jovicic

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Publications associées (4)

Veuillez noter qu'il ne s'agit pas d'une liste complète des publications de cette personne. Elle inclut uniquement les travaux sémantiquement pertinents. Pour une liste complète, veuillez consulter Infoscience.

Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations

Hilal Lashuel, Bruno Claude Daniel Fauvet, Anne-Laure Mahul Mellier, Carole Desobry, Farah El Turk, Ana Jovicic

Alpha-synuclein is a presynaptic protein of poorly understood function that is linked to both genetic and sporadic forms of Parkinson's disease. We have proposed that alpha-synuclein may function specifically at synaptic vesicles docked at the plasma membr ...

Amer Chemical Soc2016

The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of alpha-synuclein, and enhances its secretion and nuclear localization in cells

Hilal Lashuel, Nadine Aït Bouziad, Mohamed Bilal Fares, Martial Mbefo Kamdem, Ana Jovicic

A novel mutation in the alpha-Synuclein (alpha-Syn) gene "G51D" was recently identified in two familial cases exhibiting features of Parkinson's disease (PD) and multiple system atrophy (MSA). In this study, we explored the impact of this novel mutation on ...

Oxford University Press2014

MicroRNA-22 (miR-22) Overexpression Is Neuroprotective via General Anti-Apoptotic Effects and May also Target Specific Huntington's Disease-Related Mechanisms

Background: Whereas many causes and mechanisms of neurodegenerative diseases have been identified, very few therapeutic strategies have emerged in parallel. One possible explanation is that successful treatment strategy may require simultaneous targeting o ...

Public Library Science2013