Telomere are the protective terminal structures of linear chromosomes. The repetitive TTAGGG sequences are bound by the dedicated shelterin complex, as well as by histones carrying modifications characteristic of silent chromatin. Like the centromeric hete ...
The control of telomerase activity at chromosome ends by telomere-binding proteins is critical for telomere length homeostasis. Two recent papers identify TPP1 as a critical mediator of this control. TPP1 forms part of the telomeric shelterin complex while ...
Telomerase is required for telomere maintenance and is responsible for the immortal phenotype of cancer cells. How telomerase is assembled and reaches telomeres in the context of nuclear architecture is not understood. Recently, the telomerase RNA subunit ...
