Stephane Kontos

Cette personne n’est plus à l’EPFL

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Publications associées (13)

Engineered aprotinin for improved stability of fibrin biomaterials

Jeffrey Alan Hubbell, Peter Frey, Stephane Kontos, Kristen Lorentz

Fibrin has been long used clinically for hemostasis and sealing, yet extension of use in other applications has been limited due to its relatively rapid resorption in vivo, even with addition of aprotinin or other protease inhibitors. We report an engineer ...

2011

Engineering integrin signaling for promoting embryonic stem cell self-renewal in a precisely defined niche

Jeffrey Alan Hubbell, Stephane Kontos, Seung Tae Lee, Yun Suk Jo, Jong Eun Ihm, Mayumi Mochizuki Martino, Jungim Yun

We present development and use of a 3D synthetic extracellular matrix (ECM) analog with integrin- specific adhesion ligands to characterize the microenvironmental influences in embryonic stem cell (ESC) self-renewal. Transcriptional analysis of 24 integrin ...

Elsevier2010

Improving Protein Pharmacokinetics by Engineering Erythrocyte Affinity

Jeffrey Alan Hubbell, Stephane Kontos

Poor pharmacokinetic profiles are often the underlying reason for the failure of novel protein drugs to reach clinical translation. Current passive half-life improvement methods focus on increasing the apparent hydrodynamic radius of the drug. We sought to ...

American Chemical Society2010

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